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KKL-10

Name: KKL-10
Brand: TargetMol
SKU: T4222
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4222Cas No. 952849-76-2

Alias KKL 10

KKL-10, a ribosome rescue inhibitor, has broad-spectrum antimicrobial activity against bacteria.

KKL-10

😃Good

Purity: 98.59%

Catalog No. T4222Alias KKL 10Cas No. 952849-76-2

KKL-10, a ribosome rescue inhibitor, has broad-spectrum antimicrobial activity against bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
2 mg	$50	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$137	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$662	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.59%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	KKL-10, a ribosome rescue inhibitor, has broad-spectrum antimicrobial activity against bacteria.
In vitro	KKL-10 shows markedly antimicrobial activity against both fully and attenuated virulent strains of F. tularensis. The MIC against F. tularensis strain Schu S4 and LVS are 0.48 and 0.12 μg/mL, respectively. KKL-10 inhibits the intracellular growth of F. tularensis during all stages of infection. KKL-10 cannot affect macrophage function or viability. KKL-10 (17.5 μg/mL) produces cytotoxic effects of less than 5%. The combination of IFN-γ stimulation and KKL-10 can reduce the bacterial load by >99.9%. KKL-10 also inhibits the growth of F. tularensis inside eukaryotic cells and exhibits no toxicity to HepG2 cells.
Synonyms	KKL 10

Chemical Properties

Molecular Weight	364.22
Formula	C₁₄H₁₀BrN₃O₂S
Cas No.	952849-76-2
Smiles	Cc1ccc(cc1)-c1nnc(NC(=O)c2ccc(Br)s2)o1
Relative Density.	1.620 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.65 mg/mL (10.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7456 mL	13.7280 mL	27.4559 mL	137.2797 mL
5 mM	0.5491 mL	2.7456 mL	5.4912 mL	27.4559 mL
10 mM	0.2746 mL	1.3728 mL	2.7456 mL	13.7280 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc