Shopping Cart

Your shopping cart is currently empty

PHGDH-IN-3

Name: PHGDH-IN-3
Brand: TargetMol
SKU: T73143
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T73143Cas No. 2893778-31-7

PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.

PHGDH-IN-3

🥰Excellent

Purity: 99.1%

Catalog No. T73143Cas No. 2893778-31-7

PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$239	In Stock	In Stock
10 mg	$355	In Stock	In Stock
25 mg	$569	In Stock	In Stock
50 mg	$762	In Stock	In Stock
100 mg	$987	In Stock	In Stock
500 mg	$1,980	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.1%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.
Targets&IC50	PHGDH:2.33 μM, PHGDH:2.8 μM
In vitro	PHGDH-IN-3 (compound D8) exhibits strong enzymatic inhibitory activity with an IC50 value of 2.8 μM and demonstrates high binding affinity for PHGDH protein with a Kd value of 2.33 μM. It is particularly effective against cell lines with amplified or overexpressed PHGDH genes and restricts de novo serine synthesis from glucose in MDA-MB-468 cells.[1]
In vivo	PHGDH-IN-3 (compound D8) (1, 3 mg/kg; p.o., i.v.) exhibits excellent in vivo pharmacokinetic properties.[1] Additionally, PHGDH-IN-3 (12.5, 25, 50 mg/kg; i.p.; once daily for 31 days) demonstrated significant antitumor effects in a PC9 xenograft mouse model.[1]

Chemical Properties

Molecular Weight	495.55
Formula	C₂₄H₁₈FN₃O₄S₂
Cas No.	2893778-31-7
Smiles	N(C(=O)C1=CC=C(S(NC2=CC(C(C)=O)=CC=C2)(=O)=O)C=C1)C3=NC(=CS3)C4=CC(F)=CC=C4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (181.62 mM), Sonication and heating to 70℃ are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (10.09 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0180 mL	10.0898 mL	20.1796 mL	100.8980 mL
5 mM	0.4036 mL	2.0180 mL	4.0359 mL	20.1796 mL
10 mM	0.2018 mL	1.0090 mL	2.0180 mL	10.0898 mL
20 mM	0.1009 mL	0.5045 mL	1.0090 mL	5.0449 mL
50 mM	0.0404 mL	0.2018 mL	0.4036 mL	2.0180 mL
100 mM	0.0202 mL	0.1009 mL	0.2018 mL	1.0090 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc