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PHGDH-IN-3

Catalog No. T73143 CAS 2893778-31-7

PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about cancer.

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PHGDH-IN-3, CAS 2893778-31-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 478.00
25 mg	In stock	$ 783.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,480.00
500 mg	In stock	$ 2,950.00

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Purity: 99.47%

Purity: 98.99%

Purity: 97.24%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about cancer.
Targets&IC50	PHGDH:2.8 μM, PHGDH:2.33 μM
In vitro	PHGDH-IN-3 (compound D8) has good enzymatic inhibitory activity with an IC50 value of 2.8 μM.[1] PHGDH-IN-3 has a high binding affinity for PHGDH protein with a Kd value of 2.33 μM.[1] PHGDH-IN-3 is sensitive to cell lines with amplified or overexpressed PHGDH genes.[1] PHGDH-IN-3 restricts the de novo synthesis of serine from glucose in MDA-MB-468 cells.[1]
In vivo	PHGDH-IN-3 (compound D8) (1, 3 mg/kg; p.o., i.v.; ) exhibits excellent in vivo pharmacokinetic properties.[1] PHGDH-IN-3 (12.5, 25, 50 mg/kg; i.p.; once daily for 31 days) exerted significant antitumor effects in a PC9 xenograft mouse model.[1]

Molecular Weight	495.55
Formula	C24H18FN3O4S2
CAS No.	2893778-31-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (181.6 mM), Sonication and heating to 70℃ are recommended.

References and Literature

1. Gao D, et al. Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy. J Med Chem. 2023;66(1):285-305.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PHGDH-IN-3 2893778-31-7 Metabolism Dehydrogenase inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.