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Thalidomide-O-amido-PEG3-C2-NH2 TFA

🥰Excellent
Catalog No. T7758Cas No. 1957236-21-3
Alias E3 ligase Ligand-Linker Conjugates 14 TFA, Cereblon Ligand-Linker Conjugates 3 (TFA)

Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) is a synthesized E3 ligase ligand-linker conjugate incorporating a Thalidomide-based cereblon ligand and a 3-unit PEG linker, used in PROTAC technology.

Thalidomide-O-amido-PEG3-C2-NH2 TFA
Other Forms of Thalidomide-O-amido-PEG3-C2-NH2 TFA:
Thalidomide-O-amido-PEG3-C2-NH2T179151957236-20-2
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Thalidomide-O-amido-PEG3-C2-NH2 TFA

🥰Excellent
Purity: 99.82%
Catalog No. T7758Alias E3 ligase Ligand-Linker Conjugates 14 TFA, Cereblon Ligand-Linker Conjugates 3 (TFA)Cas No. 1957236-21-3
Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) is a synthesized E3 ligase ligand-linker conjugate incorporating a Thalidomide-based cereblon ligand and a 3-unit PEG linker, used in PROTAC technology.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$33In StockIn Stock
25 mgPreferentialIn StockIn Stock
50 mgPreferentialIn StockIn Stock
1 mL x 10 mM (in DMSO)$35In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.82%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) is a synthesized E3 ligase ligand-linker conjugate incorporating a Thalidomide-based cereblon ligand and a 3-unit PEG linker, used in PROTAC technology.
SynonymsE3 ligase Ligand-Linker Conjugates 14 TFA, Cereblon Ligand-Linker Conjugates 3 (TFA)
Chemical Properties
Molecular Weight620.54
FormulaC25H31F3N4O11
Cas No.1957236-21-3
SmilesC1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCN.C(=O)(C(F)(F)F)O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (80.58 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6115 mL8.0575 mL16.1150 mL80.5750 mL
5 mM0.3223 mL1.6115 mL3.2230 mL16.1150 mL
10 mM0.1611 mL0.8057 mL1.6115 mL8.0575 mL
20 mM0.0806 mL0.4029 mL0.8057 mL4.0287 mL
50 mM0.0322 mL0.1611 mL0.3223 mL1.6115 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

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