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PQM130

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Catalog No. T12532Cas No. 2089415-51-8

PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies.

PQM130

PQM130

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🥰Excellent
Purity: 98.73%
Catalog No. T12532Cas No. 2089415-51-8
PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$38In StockIn Stock
25 mg$77In StockIn Stock
50 mg$128In StockIn Stock
100 mg$207In StockIn Stock
200 mg$297In StockIn Stock
1 mL x 10 mM (in DMSO)$36In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.73%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 can be used in anti-AD studies.
In vitro
PQM130 had already shown anti-inflammatory activity in different in vivo models and neuroprotective activity in human neuronal cells.
In vivo
The intracerebroventricular (i.c.v.) injection of AβO in mice caused the increase of memory impairment, oxidative stress, neurodegeneration, and neuroinflammation.?Instead, PQM130 (0.5-1 mg/kg) treatment after the i.c.v. AβO injection reduced oxidative damage and neuroinflammation and induced cell survival and protein synthesis through the modulation of glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinases (ERK1/2).?Moreover, PQM130 increased brain plasticity and protected mice against the decline in spatial cognition.?PQM130 modulated different pathways compared to donepezil, and it is much more effective in counteracting AβO damage.
Chemical Properties
Molecular Weight381.46
FormulaC23H27NO4
Cas No.2089415-51-8
SmilesCOc1cc(\C=C\C(=O)OCC2CCN(Cc3ccccc3)CC2)ccc1O
Relative Density.1.174 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5.5 mg/mL (14.42 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6215 mL13.1075 mL26.2151 mL131.0753 mL
5 mM0.5243 mL2.6215 mL5.2430 mL26.2151 mL
10 mM0.2622 mL1.3108 mL2.6215 mL13.1075 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-amyloid peptideβAmyloidβ AmyloidPQM-130PQM130PQM 130InhibitorinhibitBetaAmyloidBeta AmyloidbAmyloidb AmyloidAβ1-42Amyloid-βAbeta
Related Tags: buy PQM130 | purchase PQM130 | PQM130 cost | order PQM130 | PQM130 chemical structure | PQM130 in vivo | PQM130 in vitro | PQM130 formula | PQM130 molecular weight
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