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Ursonic Acid

Name: Ursonic Acid
Brand: TargetMol
SKU: T3323
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3323Cas No. 6246-46-4

Alias TOS-BB-0966, Prunol, NSC4060, Malol, CCRIS 7123, 3-Ketoursolic acid

Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor.

Ursonic Acid

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Purity: 99.48%

Catalog No. T3323Alias TOS-BB-0966, Prunol, NSC4060, Malol, CCRIS 7123, 3-Ketoursolic acidCas No. 6246-46-4

Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$135	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Ursonic Acid AI Summary

Ursonic Acid exhibits a broad spectrum of bioactivity across various biological targets and cell lines. It demonstrates significant antiviral activity against HSV1 MacIntyre and HSV2 MS in African green monkey Vero cells, with IC50 values of 2.5 µg/mL and 8.0 µg/mL, respectively. Additionally, it shows inhibitory potential against glycogen phosphorylase A in rabbit muscle with an IC50 of 57000 nM and exhibits weak inhibition of aromatase in human placental microsomes with an IC50 greater than 500,000 nM. Ursonic Acid also acts as an HIV1 protease inhibitor at 37500 nM. In terms of cytotoxicity, Ursonic Acid inhibits the growth of several human cell lines, including NTUB1, AsPC1, MDA-MB-231, HepG2, and SMMC-7221, with IC50 values typically in the range of 21440 nM to 24500 nM. It also shows cytotoxicity against HeLa, MDA-MB-231, and SMMC7721 cell lines with IC50 values exceeding 40000 nM and demonstrates varying levels of growth inhibition in MCF7, HCT116, A549, THP1, and FR2 cells at 50 µM concentration. Furthermore, Ursonic Acid exhibits antimicrobial activity against various bacterial strains, including Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, and Bacillus subtilis, with MIC values ranging from 31.2 to 62.5 µg/mL. It also shows activity against fungal strains such as Aspergillus niger, Candida albicans, and Candida tropicalis with higher MIC values. It inhibits cathepsin D with an IC50 of 6.41 µg/mL and reduces nitric oxide production in mouse RAW264.7 cells with an IC50 of 4940 nM. Additionally, Ursonic Acid exhibits antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 with a calculated selectivity index greater than 16.48, suggesting potential for treating malaria. Altogether, Ursonic Acid demonstrates multifaceted bioactivity, including antiviral, enzyme inhibition, antimicrobial, antiplasmodial, and cytotoxic properties, with variable potency across different targets and cell types..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor.
Synonyms	TOS-BB-0966, Prunol, NSC4060, Malol, CCRIS 7123, 3-Ketoursolic acid

Chemical Properties

Molecular Weight	454.68
Formula	C₃₀H₄₆O₃
Cas No.	6246-46-4
Smiles	[H][C@@]12[C@@H](C)[C@H](C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CCC(=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O
Relative Density.	1.09 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 58.8 mg/mL (129.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1993 mL	10.9967 mL	21.9935 mL	109.9674 mL
5 mM	0.4399 mL	2.1993 mL	4.3987 mL	21.9935 mL
10 mM	0.2199 mL	1.0997 mL	2.1993 mL	10.9967 mL
20 mM	0.1100 mL	0.5498 mL	1.0997 mL	5.4984 mL
50 mM	0.0440 mL	0.2199 mL	0.4399 mL	2.1993 mL
100 mM	0.0220 mL	0.1100 mL	0.2199 mL	1.0997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc