PCSK9 Protein, Human, Recombinant (His)

Name: PCSK9 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-00895
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Proprotein convertase subtilisin/kexin type 9, PCSK9, NARC1) Copy Product Info

Synonyms: Proprotein convertase subtilisin/kexin type 9, PCSK9, NARC1

Catalog No. TMPY-00895 Copy Product Info

PCSK9 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q8NBP7-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$100	-	In Stock
10 µg	$163	-	In Stock
20 µg	$269	-	In Stock
50 µg	$533	-	In Stock
100 µg	$787	-	In Stock
200 µg	$1,160	-	In Stock
500 µg	$1,960	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human PCSK9, His Tag at 2 μg/ml (100 μl/Well) on the plate. Dose response curve for Anti-PCSK9 antibody, hFc Tag with the EC50 of 0.13 μg/ml determined by ELISA (QC Test). Human LDLR, His Tag immobilized on CM5 Chip can bind Human PCSK9, His Tag with an affinity constant of 0.35 nM as determined in SPR assay (Biacore T200).
Description	PCSK9 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q8NBP7-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q8NBP7-1
Construction	Gln31-Gln692
Protein Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in 20mM PB, 300mM NaCl, 10% Glycerol (pH 7.4).
Synonyms	Proprotein convertase subtilisin/kexin type 9, PCSK9, NARC1
Research Background	Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

Chemical Properties

Molecular Weight	Due to autocatalytic cleavage, the protein release the pro-form (59 kDa) and mature form (14 kDa). Due to glycosylation, the protein migrates to 65-68 kDa (pro-form) and 15kDa (mature form) based on Bis-Tris PAGE result.
Relative Density.	no data available

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.