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CRA-2059

Name: CRA-2059
Brand: TargetMol
SKU: T40195
Price: 397 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40195Cas No. 256649-36-2

Alias CRA2059

CRA-2059 is a selective and reversible inhibitor of human tryptase beta, exhibiting a Ki value of 620 pM against recombinant human tryptase beta (rHTβ).

CRA-2059

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Purity: 97.68%

Catalog No. T40195Alias CRA2059Cas No. 256649-36-2

CRA-2059 is a selective and reversible inhibitor of human tryptase beta, exhibiting a Ki value of 620 pM against recombinant human tryptase beta (rHTβ).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$397	-	In Stock
5 mg	$970	-	In Stock
10 mg	$1,290	-	In Stock
25 mg	$1,950	-	In Stock
50 mg	$2,620	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.68%

ee:100%

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Product Introduction

Bioactivity

Description	CRA-2059 is a selective and reversible inhibitor of human tryptase beta, exhibiting a Ki value of 620 pM against recombinant human tryptase beta (rHTβ).
Targets&IC50	rHTβ:620 pM (Ki)
In vitro	The properties of the CRA-2059:HTbeta interaction were defined in this study. Tight-binding reversible inhibition was observed with an inhibition constant (Ki) of 620 pM, an association rate constant of 7x10(7) M(-1) s(-1) and a relatively slow dissociation rate constant of 0.04 s(-1) [1].
Synonyms	CRA2059

Chemical Properties

Molecular Weight	750.82
Formula	C₃₄H₄₆N₁₂O₈
Cas No.	256649-36-2
Smiles	O(C(=O)N1CCN(C(NCC2=CC=C(NC(=N)N)C=C2)=O)CC1)[C@H]3C4C([C@H](OC(=O)N5CCN(C(NCC6=CC=C(NC(=N)N)C=C6)=O)CC5)CO4)OC3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc