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10-Formyl-5,8-dideazafolic acid

🥰Excellent
Catalog No. T62996Cas No. 61038-31-1

10-Formyl-5,8-dideazafolic acid (CB3717) is a water-soluble analog of folic acid, also known as folate. Folate is a member of the B-vitamin family, which plays a supporting role in a number of key biochemical reactions in the body, including RNA and DNA synthesis. Made up of pteridine, para-aminobenzoic acid, and glutamate, 10-Formyl-5,8-dideazafolic acid is a compound that inhibits de novo folate metabolism. It induces cell cycle arrest at phase G(1)-S, disrupts repair of cells damaged by radiation, and induces apoptosis.

10-Formyl-5,8-dideazafolic acid

10-Formyl-5,8-dideazafolic acid

🥰Excellent
Purity: 96.04%
Catalog No. T62996Cas No. 61038-31-1
10-Formyl-5,8-dideazafolic acid (CB3717) is a water-soluble analog of folic acid, also known as folate. Folate is a member of the B-vitamin family, which plays a supporting role in a number of key biochemical reactions in the body, including RNA and DNA synthesis. Made up of pteridine, para-aminobenzoic acid, and glutamate, 10-Formyl-5,8-dideazafolic acid is a compound that inhibits de novo folate metabolism. It induces cell cycle arrest at phase G(1)-S, disrupts repair of cells damaged by radiation, and induces apoptosis.
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2 mg$399In Stock
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Purity:96.04%
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COA HNMR HPLC MS

Product Introduction

Bioactivity
Description
10-Formyl-5,8-dideazafolic acid (CB3717) is a water-soluble analog of folic acid, also known as folate. Folate is a member of the B-vitamin family, which plays a supporting role in a number of key biochemical reactions in the body, including RNA and DNA synthesis. Made up of pteridine, para-aminobenzoic acid, and glutamate, 10-Formyl-5,8-dideazafolic acid is a compound that inhibits de novo folate metabolism. It induces cell cycle arrest at phase G(1)-S, disrupts repair of cells damaged by radiation, and induces apoptosis.
Chemical Properties
Molecular Weight467.43
FormulaC22H21N5O7
Cas No.61038-31-1
SmilesNc1nc(=O)c2cc(CN(C=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (64.18 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1394 mL10.6968 mL21.3936 mL106.9679 mL
5 mM0.4279 mL2.1394 mL4.2787 mL21.3936 mL
10 mM0.2139 mL1.0697 mL2.1394 mL10.6968 mL
20 mM0.1070 mL0.5348 mL1.0697 mL5.3484 mL
50 mM0.0428 mL0.2139 mL0.4279 mL2.1394 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Thymidylate SynthaseRNASynthesisRNA SynthesisDNASynthesisDNA Synthesis
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