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SDF-1 Protein, Human, Recombinant (isoform a)

Catalog No. TMPY-02820
Synonyms: SDF1, chemokine (C-X-C motif) ligand 12, IRH, SCYB12, TPAR1, SDF-1, TLSF, PBSF

SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SDF-1 Protein, Human, Recombinant (isoform a)
Pack Size Availability Price/USD Quantity
20 μg In stock $ 136.00
100 μg 5 days $ 397.00
200 μg 5 days $ 674.00
500 μg 5 days $ 1,350.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Testing in progress
Description SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
Species Human
Expression System E. coli
Tag Tag Free
Accession Number P48061-2
Synonyms SDF1, chemokine (C-X-C motif) ligand 12, IRH, SCYB12, TPAR1, SDF-1, TLSF, PBSF
Construction The Human CXCL12 isoform alpha (P48061-2) (Lys 22-Lys 89) was expressed and purified.
Protein Purity ≥ 95 % as determined by SDS-PAGE

Molecular Weight 8 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. CXCL12 and CXCR4 that have been widely characterized in peripheral tissues and delineate their main functions in the CNS. Extensive evidence supports CXCL12 as a key regulator for early development of the CNS. In the mature CNS, CXCL12 modulates neurotransmission, neurotoxicity and neuroglial interactions. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism. Although considered an important factor in normal bone metabolism, recent studies implicate CXCL12 in the pathogenesis of several diseases involving the skeleton, including rheumatoid arthritis and cancers that metastasize to bone. The CXCL12/CXCR4 axis is involved in tumor progression, angiogenesis, metastasis, and survival. Pathologically enhanced CXCL12 signaling may promote the formation of new vessels through recruiting circulating endothelial progenitor cells or directly enhancing the migration/growth of endothelial cells. Therefore, CXCL12 signaling represents an important mechanism that regulates brain tumor angiogenesis/vasculogenesis and may provide potential targets for anti-angiogenic therapy in malignant gliomas.

References and Literature

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Keywords

SDF-1 Protein, Human, Recombinant (isoform a) SCYB 12 SDF1 chemokine (C-X-C motif) ligand 12 IRH SCYB12 TPAR1 SDF-1 TPAR 1 TPAR-1 TLSF SDF 1 SCYB-12 PBSF recombinant recombinant-proteins proteins protein

 

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