DMPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) with biotin modification and carboxyl termini can couple with other biomolecules. These functional nanoparticles are useful for targeted labeling of specific cell proteins. Utilizing streptavidin as a linker, biotinylated PEG lipid conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling practical applications in fluorescence-based imaging and sensing.