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Anti-Phospho-HER2/ERBB2 (Tyr1139) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HER2/ERBB2 (Tyr1139). Anti-Phospho-HER2/ERBB2 (Tyr1139) Polyclonal Antibody can be used in IHC-P,IF(paraffin section),WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $218 | 7-10 days | |
100 μL | $317 | 7-10 days |
Description | Anti-Phospho-HER2/ERBB2 (Tyr1139) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HER2/ERBB2 (Tyr1139). Anti-Phospho-HER2/ERBB2 (Tyr1139) Polyclonal Antibody can be used in IHC-P,IF(paraffin section),WB. |
Ig Type | IgG |
Reactivity | Human,Mouse,Rat |
Application | |
Recommended Dose | IHC-P 1:50-200 WB: 1:500-2000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Construction | Polyclonal Antibody |
Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Appearance | Liquid |
Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Research Background | erb-b2 receptor tyrosine kinase 2(ERBB2) Homo sapiens This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d |
Conjucates | Unconjugated |
Others Formats | Phospho |
Immunogen | A synthesized phosphopeptide: human HER2 around the phosphorylation site of Tyr1139 |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Actual: 180 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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