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LAS101057

Name: LAS101057
Brand: TargetMol
SKU: T15715
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15715Cas No. 925676-48-8

LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.

LAS101057

🥰Excellent

Purity: 99.03%

Catalog No. T15715Cas No. 925676-48-8

LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$49	-	In Stock
10 mg	$69	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$49	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.03%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.
In vivo	At 3 mg/kg, LAS101057 effectively prevents Acetyl-β-methylcholine-induced airway hyperresponsiveness (AHR), and at 10 mg/kg, it inhibits AHR to levels similar to those achieved by 1 mg/kg of Hexadecadrol[1].

Chemical Properties

Molecular Weight	335.34
Formula	C₁₈H₁₄FN₅O
Cas No.	925676-48-8
Smiles	Fc1cnccc1-c1ncc(NC(=O)C2CC2)nc1-c1cccnc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (298.2 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9820 mL	14.9102 mL	29.8205 mL	149.1024 mL
5 mM	0.5964 mL	2.9820 mL	5.9641 mL	29.8205 mL
10 mM	0.2982 mL	1.4910 mL	2.9820 mL	14.9102 mL
20 mM	0.1491 mL	0.7455 mL	1.4910 mL	7.4551 mL
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9820 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4910 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc