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LAS101057

Name: LAS101057
Brand: TargetMol
SKU: T15715
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15715Cas No. 925676-48-8

LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.

LAS101057

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Purity: 99.03%

Catalog No. T15715Cas No. 925676-48-8

LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$49	-	In Stock
10 mg	$69	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$49	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.03%

Appearance:Solid

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	LAS101057 is a novel orally available and potent and selective A2B receptor antagonist for the study of asthma.
In vivo	At 3 mg/kg, LAS101057 effectively prevents Acetyl-β-methylcholine-induced airway hyperresponsiveness (AHR), and at 10 mg/kg, it inhibits AHR to levels similar to those achieved by 1 mg/kg of Hexadecadrol[1].

Chemical Properties

Molecular Weight	335.34
Formula	C₁₈H₁₄FN₅O
Cas No.	925676-48-8
Smiles	Fc1cnccc1-c1ncc(NC(=O)C2CC2)nc1-c1cccnc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (298.2 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9820 mL	14.9102 mL	29.8205 mL	149.1024 mL
5 mM	0.5964 mL	2.9820 mL	5.9641 mL	29.8205 mL
10 mM	0.2982 mL	1.4910 mL	2.9820 mL	14.9102 mL
20 mM	0.1491 mL	0.7455 mL	1.4910 mL	7.4551 mL
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9820 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4910 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc