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Anti-TLR7 Polyclonal Antibody
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Catalog No. TMAB-01859
Anti-TLR7 Polyclonal Antibody is a Rabbit antibody targeting TLR7. Anti-TLR7 Polyclonal Antibody can be used in WB.
Anti-TLR7 Polyclonal Antibody
Anti-TLR7 Polyclonal Antibody
😃Good
Catalog No. TMAB-01859
Anti-TLR7 Polyclonal Antibody is a Rabbit antibody targeting TLR7. Anti-TLR7 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-TLR7 Polyclonal Antibody is a Rabbit antibody targeting TLR7. Anti-TLR7 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | Sample: Lane 1: Human THP-1 (LPS) cell lysates Lane 2: Human THP-1 cell lysates Lane 3: Human Jurkat cell lysates Lane 4: Human MCF-7 cell lysates Lane 5: Human 293T cell lysates Primary: Anti-TLR7 (TMAB-01859) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 121 kDa Observed band size: 65,121 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. |
| Tissue Specificity | Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| Immunogen | KLH conjugated synthetic peptide: human TLR7 |
| Antigen Species | Human |
| Gene Name | TLR7 |
| Gene ID | |
| Protein Name | Toll-like receptor 7 |
| Uniprot ID | |
| Biology Area | Developmental Families,Receptors,Macrophage / Inflamm.,TLR Signaling,Transmembrane |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| Molecular Weight | Theoretical: 121 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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