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Anti-TGF beta 1 Antibody (4C697)

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Catalog No. TMAY-01176
Alias transforming growth factor, β1, transforming growth factor, beta 1, TGF β1

Anti-TGF beta 1 Antibody (4C697) is a Mouse antibody targeting TGF beta 1. Anti-TGF beta 1 Antibody (4C697) can be used in ICC/IF.

Anti-TGF beta 1 Antibody (4C697)

Anti-TGF beta 1 Antibody (4C697)

😃Good
Catalog No. TMAY-01176Alias transforming growth factor, β1, transforming growth factor, beta 1, TGF β1
Anti-TGF beta 1 Antibody (4C697) is a Mouse antibody targeting TGF beta 1. Anti-TGF beta 1 Antibody (4C697) can be used in ICC/IF.
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100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-TGF beta 1 Antibody (4C697) is a Mouse antibody targeting TGF beta 1. Anti-TGF beta 1 Antibody (4C697) can be used in ICC/IF.
Aliastransforming growth factor, β1, transforming growth factor, beta 1, TGF β1
Ig Type
Monoclonal Mouse IgG1
Clone
4C697
Reactivity
Human
Verified Activity
Immunofluorescence staining of TGFβ1 in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with mouse anti-Human TGFβ1 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
Application
ICC/IF
Recommended Dose
ICC-IF: 1:20-1:100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis product is a recombinant monoclonal antibody expressed from HEK293 cells.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human TGF beta 1 Protein (TMPY-01133)
Antigen Species
Human
Biology Area
Early Mesodermal Lineage Markers, Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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