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4-PPBP maleate

🥰Excellent
Catalog No. T22513Cas No. 201216-39-9

4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.

4-PPBP maleate

4-PPBP maleate

🥰Excellent
Purity: 99.88%
Catalog No. T22513Cas No. 201216-39-9
4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$48In Stock
25 mg$96In Stock
50 mg$155In Stock
100 mg$230In Stock
200 mg$326In Stock
1 mL x 10 mM (in DMSO)$36In Stock
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Batch Information

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Purity:99.88%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
In vitro
ERK1/2 phosphorylation is induced by 4-PPBP maleate in primary neurons.[3]
In vivo
In rats, administration of 4-PPBP maleate (1 μmol/kg; i.v.) leads to a reduction in brain injury following transient focal ischemia.[2]
Chemical Properties
Molecular Weight409.52
FormulaC25H31NO4
Cas No.201216-39-9
SmilesC(=C\C(O)=O)\C(O)=O.C(CCCC1=CC=CC=C1)N2CCC(CC2)C3=CC=CC=C3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: < 10.24 mg/mL, Sonication is recommended.
DMSO: 225.0 mg/mL (549.4 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4419 mL12.2094 mL24.4188 mL122.0942 mL
5 mM0.4884 mL2.4419 mL4.8838 mL24.4188 mL
10 mM0.2442 mL1.2209 mL2.4419 mL12.2094 mL
20 mM0.1221 mL0.6105 mL1.2209 mL6.1047 mL
50 mM0.0488 mL0.2442 mL0.4884 mL2.4419 mL
100 mM0.0244 mL0.1221 mL0.2442 mL1.2209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

σSigmareceptorSigma receptorNR1a/2B NMDA receptor4-PPBP Maleate4PPBP maleate4 PPBP maleate
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