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4-PPBP maleate

Name: 4-PPBP maleate
Brand: TargetMol
SKU: T22513
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22513Cas No. 201216-39-9

4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.

4-PPBP maleate

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Purity: 99.88%

Catalog No. T22513Cas No. 201216-39-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	-	In Stock
10 mg	$48	-	In Stock
25 mg	$96	-	In Stock
50 mg	$155	-	In Stock
100 mg	$230	-	In Stock
200 mg	$326	-	In Stock
1 mL x 10 mM (in DMSO)	$36	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.
In vitro	ERK1/2 phosphorylation is induced by 4-PPBP maleate in primary neurons.[3]
In vivo	In rats, administration of 4-PPBP maleate (1 μmol/kg; i.v.) leads to a reduction in brain injury following transient focal ischemia.[2]

Chemical Properties

Molecular Weight	409.52
Formula	C₂₅H₃₁NO₄
Cas No.	201216-39-9
Smiles	C(=C\C(O)=O)\C(O)=O.C(CCCC1=CC=CC=C1)N2CCC(CC2)C3=CC=CC=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 10.24 mg/mL, Sonication is recommended.

DMSO: 225 mg/mL (549.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4419 mL	12.2094 mL	24.4188 mL	122.0942 mL
5 mM	0.4884 mL	2.4419 mL	4.8838 mL	24.4188 mL
10 mM	0.2442 mL	1.2209 mL	2.4419 mL	12.2094 mL
20 mM	0.1221 mL	0.6105 mL	1.2209 mL	6.1047 mL
50 mM	0.0488 mL	0.2442 mL	0.4884 mL	2.4419 mL
100 mM	0.0244 mL	0.1221 mL	0.2442 mL	1.2209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc