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Anti-IGF2/IGF-II Antibody (1H183)
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Catalog No. TMAY-03053
Alias PP9974, insulin-like growth factor 2, IGF-II, C11orf43
Anti-IGF2/IGF-II Antibody (1H183) is a Rabbit antibody targeting IGF2/IGF-II. Anti-IGF2/IGF-II Antibody (1H183) can be used in ELISA.
Anti-IGF2/IGF-II Antibody (1H183)
Anti-IGF2/IGF-II Antibody (1H183)
😃Good
Catalog No. TMAY-03053Alias PP9974, insulin-like growth factor 2, IGF-II, C11orf43
Anti-IGF2/IGF-II Antibody (1H183) is a Rabbit antibody targeting IGF2/IGF-II. Anti-IGF2/IGF-II Antibody (1H183) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Mouse |
| Alias | PP9974, insulin-like growth factor 2, IGF-II, C11orf43 |
| Ig Type | Rabbit IgG |
| Clone | 1H183 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IGF-2/IGF-II (rM IGF-2/IGF-II; P09535Ala25-Glu91). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumors. It binds to at least two different types of receptors: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumor suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. This study aimed to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse IGF-2/IGF-II Protein |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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