Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-IGF2/IGF-II Antibody (1H183)

😃Good
Catalog No. TMAY-03053
Alias PP9974, insulin-like growth factor 2, IGF-II, C11orf43

Anti-IGF2/IGF-II Antibody (1H183) is a Rabbit antibody targeting IGF2/IGF-II. Anti-IGF2/IGF-II Antibody (1H183) can be used in ELISA.

Anti-IGF2/IGF-II Antibody (1H183)

Anti-IGF2/IGF-II Antibody (1H183)

😃Good
Catalog No. TMAY-03053Alias PP9974, insulin-like growth factor 2, IGF-II, C11orf43
Anti-IGF2/IGF-II Antibody (1H183) is a Rabbit antibody targeting IGF2/IGF-II. Anti-IGF2/IGF-II Antibody (1H183) can be used in ELISA.
Pack SizePriceAvailabilityQuantity
100 μL$270 7-10 days
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Anti-IGF2/IGF-II Antibody (1H183) is a Rabbit antibody targeting IGF2/IGF-II. Anti-IGF2/IGF-II Antibody (1H183) can be used in ELISA.
AliasPP9974, insulin-like growth factor 2, IGF-II, C11orf43
Ig Type
Monoclonal Rabbit IgG
Clone
1H183
Reactivity
Mouse
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse IGF-2/IGF-II (rM IGF-2/IGF-II; P09535Ala25-Glu91).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundInsulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumors. It binds to at least two different types of receptors: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumor suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. This study aimed to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Mouse IGF-2/IGF-II Protein
Antigen Species
Mouse
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

Sci Citations

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Anti-IGF2/IGF-II Antibody (1H183) | purchase Anti-IGF2/IGF-II Antibody (1H183) | Anti-IGF2/IGF-II Antibody (1H183) cost | order Anti-IGF2/IGF-II Antibody (1H183)