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ATR-IN-29

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Catalog No. T79121Cas No. 2761193-67-1

ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].

ATR-IN-29

ATR-IN-29

😃Good
Catalog No. T79121Cas No. 2761193-67-1
ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mgInquiry8-10 weeks8-10 weeks
50 mgInquiry8-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].
Targets&IC50
ATR:1 nM
In vitro
ATR-IN-29 (compound 1) exhibited antiproliferative activity over 4 days, with IC50 values of 156.70, 38.81, 22.48, 181.60, and 19.02 nM against A549, HCC1806, HCT116, OVCAR-3, and NCI-H460 cell lines, respectively [1].
In vivo
ATR-IN-29 administered at a dose of 10 mg/kg orally once demonstrated favorable pharmacokinetic parameters in CD-1 (ICR) mice, with a half-life (t1/2) of 1.64 hours, a maximum concentration (Cmax) of 9343 ng/mL, and an area under the curve from time zero to the last measurable concentration (AUC 0-t) of 98507 ng·h/mL, as well as an area under the curve from time zero to infinity (AUC 0-inf) of 98517 ng·h/mL.
Chemical Properties
Molecular Weight378.43
FormulaC19H22N8O
Cas No.2761193-67-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

ATRATM
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