Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1]. |
Targets&IC50 | ATR:1 nM |
In vitro | ATR-IN-29 (compound 1) demonstrated antiproliferative activity over 4 days, with IC50 values against A549, HCC1806, HCT116, OVCAR-3, and NCI-H460 cell lines being 156.70, 38.81, 22.48, 181.60, and 19.02 nM, respectively [1]. |
In vivo | ATR-IN-29 administered at a dose of 10 mg/kg orally once demonstrated favorable pharmacokinetic parameters in CD-1 (ICR) mice, with a half-life (t1/2) of 1.64 hours, a maximum concentration (Cmax) of 9343 ng/mL, and an area under the curve from time zero to the last measurable concentration (AUC 0-t) of 98507 ng·h/mL, as well as an area under the curve from time zero to infinity (AUC 0-inf) of 98517 ng·h/mL. |
Molecular Weight | 378.43 |
Formula | C19H22N8O |
CAS No. | 2761193-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ATR-IN-29 2761193-67-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR inhibitor inhibit