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(R)-Leucic acid (Synonyms: D-α-Hydroxyisocaproic acid)

Name: (R)-Leucic acid
Brand: TargetMol
SKU: T19539
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T19539 Copy Product Info

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(R)-Leucic acid (D-HICA) is a leucine metabolite and an orally active D-isomer of the alpha-hydroxy leucine analogue. It promotes intestinal fatty acid absorption by upregulating CD36, used for lipid metabolism studies.

(R)-Leucic acid

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Catalog No. T19539

Synonyms D-α-Hydroxyisocaproic acid

Cas No. 20312-37-2

Pack Size	Price	USA Stock	Global Stock
500 mg	$31	-	In Stock
1 g	$48	-	In Stock
1 mL x 10 mM (in DMSO)	$35	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	(R)-Leucic acid (D-HICA) is a leucine metabolite and an orally active D-isomer of the alpha-hydroxy leucine analogue. It promotes intestinal fatty acid absorption by upregulating CD36, used for lipid metabolism studies.
In vitro	(R)-Leucic acid (0.125–2 mM) induces a dose-dependent increase in triglyceride (TG) content in IPEC-J2 cells by activating the CD36 signaling pathway [1].
In vivo	In rats, dietary (R)-Leucic acid (0.1%-0.3%) shows a growth-promoting efficiency of only 41% compared to its L-isomer, with slower weight gain [2].
Synonyms	D-α-Hydroxyisocaproic acid

Chemical Properties

Molecular Weight	132.16
Formula	C₆H₁₂O₃
Cas No.	20312-37-2
Smiles	[C@@H](CC(C)C)(C(O)=O)O
Relative Density.	1.763g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (605.33 mM), Sonication is recommmended.

DMSO: 80 mg/mL (605.33 mM), Sonication is recommmended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.5666 mL	37.8329 mL	75.6659 mL	378.3293 mL
5 mM	1.5133 mL	7.5666 mL	15.1332 mL	75.6659 mL
10 mM	0.7567 mL	3.7833 mL	7.5666 mL	37.8329 mL
20 mM	0.3783 mL	1.8916 mL	3.7833 mL	18.9165 mL
50 mM	0.1513 mL	0.7567 mL	1.5133 mL	7.5666 mL
100 mM	0.0757 mL	0.3783 mL	0.7567 mL	3.7833 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc