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Tolfenamic Acid

Name: Tolfenamic Acid
Brand: TargetMol
SKU: T0784
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0784Cas No. 13710-19-5

Alias Tolfedine, GEA 6414

Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory drug (NSAID) used to treat migraine symptoms.

Tolfenamic Acid

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Purity: 99.95%

Catalog No. T0784Alias Tolfedine, GEA 6414Cas No. 13710-19-5

Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory drug (NSAID) used to treat migraine symptoms.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$33	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Tolfenamic Acid AI Summary

Tolfenamic Acid exhibits a broad range of bioactivities, including significant antiviral, anti-inflammatory, and enzyme inhibitory properties. It demonstrates the ability to undergo in vitro ester hydrolysis in 80% human plasma at 37°C, with distinctly different half-lives for methyl ester (100.0 hours) and N,N-diethylglycolamide ester (0.08333 hours) hydrolysis. Additionally, the compound displays potent anti-inflammatory effects, reducing carrageenan-induced paw edema in rats by 24.0% at specific dosages. Tolfenamic Acid shows marked antiviral activity against JC polyomavirus and modest activity against SARS-CoV-2, although its efficacy for the latter is relatively weak with an inhibition IC50 greater than 19952.62 nM. It also exhibits inhibition of the CYP2C9 enzyme (Ki of 537650433122253.3 nM), COX-2 enzyme (IC50 of 1170.0 nM), and multiple cytochrome P450 enzymes. The compound has demonstrated hepatotoxic and ulcerogenic activities, evidenced by significant toxicity in rats at 760 uM/kg over four days, leading to a 50% mortality rate and substantial body weight reduction. Tolfenamic Acid inhibits various other enzymes and targets, such as SARS-CoV-2 protease, human AKR1C3 (Ki of 8.0 nM), and HDAC6. Its binding affinity to TTR is noted, with distinct IC50 and Kd values. The diverse bioactivities presented indicate potential therapeutic applications but also highlight significant toxicity that needs to be carefully evaluated..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory drug (NSAID) used to treat migraine symptoms.
Targets&IC50	COX-2:0.2 μM
Synonyms	Tolfedine, GEA 6414

Chemical Properties

Molecular Weight	261.70
Formula	C₁₄H₁₂ClNO₂
Cas No.	13710-19-5
Smiles	N(C1=C(C(O)=O)C=CC=C1)C2=C(C)C(Cl)=CC=C2
Relative Density.	1.2037 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 49 mg/mL (187.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (7.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8212 mL	19.1058 mL	38.2117 mL	191.0585 mL
5 mM	0.7642 mL	3.8212 mL	7.6423 mL	38.2117 mL
10 mM	0.3821 mL	1.9106 mL	3.8212 mL	19.1058 mL
20 mM	0.1911 mL	0.9553 mL	1.9106 mL	9.5529 mL
50 mM	0.0764 mL	0.3821 mL	0.7642 mL	3.8212 mL
100 mM	0.0382 mL	0.1911 mL	0.3821 mL	1.9106 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc