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Tolfenamic Acid

Name: Tolfenamic Acid
Brand: TargetMol
SKU: T0784
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0784Cas No. 13710-19-5

Alias Tolfedine, GEA 6414

Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory drug (NSAID) used to treat migraine symptoms.

Tolfenamic Acid

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Purity: 99.97%

Catalog No. T0784Alias Tolfedine, GEA 6414Cas No. 13710-19-5

Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory drug (NSAID) used to treat migraine symptoms.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$33	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory drug (NSAID) used to treat migraine symptoms.
Targets&IC50	COX-2:0.2 μM
Synonyms	Tolfedine, GEA 6414

Chemical Properties

Molecular Weight	261.70
Formula	C₁₄H₁₂ClNO₂
Cas No.	13710-19-5
Smiles	N(C1=C(C(O)=O)C=CC=C1)C2=C(C)C(Cl)=CC=C2
Relative Density.	1.2037 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 49 mg/mL (187.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (7.64 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8212 mL	19.1058 mL	38.2117 mL	191.0585 mL
5 mM	0.7642 mL	3.8212 mL	7.6423 mL	38.2117 mL
10 mM	0.3821 mL	1.9106 mL	3.8212 mL	19.1058 mL
20 mM	0.1911 mL	0.9553 mL	1.9106 mL	9.5529 mL
50 mM	0.0764 mL	0.3821 mL	0.7642 mL	3.8212 mL
100 mM	0.0382 mL	0.1911 mL	0.3821 mL	1.9106 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc