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LL-37 GKE acetate, a peptide with 21 amino acids and the active structural domain of LL-37, inhibits lps-induced vascular nitric oxide production, is less toxic than LL-37 for hemolysis and apoptosis in human cultured smooth muscle cells, and possesses antimicrobial activity and therapeutic potential for sepsis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $83 | In Stock | |
5 mg | $183 | In Stock | |
10 mg | $275 | In Stock | |
25 mg | $466 | In Stock |
Description | LL-37 GKE acetate, a peptide with 21 amino acids and the active structural domain of LL-37, inhibits lps-induced vascular nitric oxide production, is less toxic than LL-37 for hemolysis and apoptosis in human cultured smooth muscle cells, and possesses antimicrobial activity and therapeutic potential for sepsis. |
In vitro | LL-37 GKE acetate, a fragment of LL-37, exhibits broad-spectrum in vitro antimicrobial activity against E. coli, P. aeruginosa, S. aureus, and C. albicans, maintaining effectiveness in 150 mM NaCl and 99% serum. LL-37 GKE acetate also neutralizes LPS-induced nitric oxide production in rat aorta and induces neutrophil chemotaxis. Compared to full-length LL-37, GKE shows lower hemolytic and cytotoxic effects, indicating improved safety[1]. |
Alias | LL-37 GKE acetate(913736-92-2 Free base) |
Molecular Weight | 2673.17 |
Formula | C121H206N38O30 |
Smiles | NCCCC[C@H](NC(CN)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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