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STAT3-IN-11

Name: STAT3-IN-11
Brand: TargetMol
SKU: T61030
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61030Cas No. 2503096-50-0

STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound for the treatment of cancer.

STAT3-IN-11

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Purity: 98.3%

Catalog No. T61030Cas No. 2503096-50-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.3%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound for the treatment of cancer.
In vitro	STAT3-IN-11 (2.5-10μM, 6 hours) dose-dependently inhibits phosphorylation of STAT3 at the pTyr705 site stimulated by IL-6 in MDA-MB-231 cells. However, it does not affect the phosphorylation of upstream kinases such as p-JAK2 and p-Src, nor the phosphorylation of STAT1, a STAT subtype.

Chemical Properties

Molecular Weight	335.35
Formula	C₂₀H₁₇NO₄
Cas No.	2503096-50-0
Smiles	CC1=C(CCNC(=O)c2ccccc2)C(=O)c2c(O)cccc2C1=O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (238.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9820 mL	14.9098 mL	29.8196 mL	149.0980 mL
5 mM	0.5964 mL	2.9820 mL	5.9639 mL	29.8196 mL
10 mM	0.2982 mL	1.4910 mL	2.9820 mL	14.9098 mL
20 mM	0.1491 mL	0.7455 mL	1.4910 mL	7.4549 mL
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9820 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4910 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc