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Anti-Smac Antibody (4E724)
🥰Excellent
Catalog No. TMAB-12933
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM
Reactivity: Human,Mouse,Rat
Anti-Smac Antibody (4E724)
Anti-Smac Antibody (4E724)
🥰Excellent
Catalog No. TMAB-12933
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM
Reactivity: Human,Mouse,Rat
Application: WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM
Reactivity: Human,Mouse,Rat
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Smac Antibody (4E724) is a Rabbit antibody targeting Smac. Anti-Smac Antibody (4E724) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM. |
| Ig Type | IgG |
| Clone | 4E724 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200; IP: 1:20-50; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion. Note=Released into the cytosol when cells undergo apoptosis. |
| Tissue Specificity | Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. |
| Immunogen | A synthesized peptide: human DIABLO |
| Antigen Species | Human |
| Gene Name | DIABLO |
| Gene ID | |
| Protein Name | Diablo homolog, mitochondrial |
| Uniprot ID | |
| Function | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. |
| Molecular Weight | Theoretical: 27 kDa. Actual: 21 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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