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Terminolic acid

🥰Excellent
Catalog No. TN6722Cas No. 564-13-6
Alias 2α,6β,23-trihydroxyl oleanolic acid

Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.

Terminolic acid

Terminolic acid

🥰Excellent
Purity: 99.14%
Catalog No. TN6722Alias 2α,6β,23-trihydroxyl oleanolic acidCas No. 564-13-6
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.
Pack SizePriceAvailabilityQuantity
1 mg$50In Stock
5 mg$112In Stock
10 mg$163In Stock
25 mg$272In Stock
50 mg$393In Stock
100 mg$588In Stock
1 mL x 10 mM (in DMSO)$170In Stock
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Purity:99.14%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.
Synonyms2α,6β,23-trihydroxyl oleanolic acid
Chemical Properties
Molecular Weight504.7
FormulaC30H48O6
Cas No.564-13-6
Smiles[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]3([H])[C@H](O)C[C@@]12C)C(O)=O
Relative Density.1.23 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (89.16 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9814 mL9.9069 mL19.8138 mL99.0688 mL
5 mM0.3963 mL1.9814 mL3.9628 mL19.8138 mL
10 mM0.1981 mL0.9907 mL1.9814 mL9.9069 mL
20 mM0.0991 mL0.4953 mL0.9907 mL4.9534 mL
50 mM0.0396 mL0.1981 mL0.3963 mL1.9814 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

triterpenoidTerminolic acidracemosumpentacyclicInhibitorinhibitinflammatoryIL-6IL-4IL-1βglucosidecytokinesCombretumBacterialantibacterial2alpha,6beta,23-trihydroxyl oleanolic acid2a,6b,23-trihydroxyl oleanolic acid
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