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Terminolic acid

Name: Terminolic acid
Brand: TargetMol
SKU: TN6722
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6722Cas No. 564-13-6

Alias 2α,6β,23-trihydroxyl oleanolic acid

Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.

Terminolic acid

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Purity: 99.14%

Catalog No. TN6722Alias 2α,6β,23-trihydroxyl oleanolic acidCas No. 564-13-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$272	In Stock	In Stock
50 mg	$393	-	In Stock
100 mg	$588	-	In Stock
1 mL x 10 mM (in DMSO)	$145	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.14%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Terminolic acid AI Summary

Terminolic acid shows limited antifungal activities and enzyme inhibitory properties. It exhibits no significant activity in inhibiting Saccharomyces cerevisiae fatty acid synthase and demonstrates IC50 values higher than 50.0 µg/mL against Candida albicans ATCC 90028 and Cryptococcus neoformans ATCC 90113. However, it shows some antifungal activity against Candida albicans, with Minimum Inhibitory Concentration (MIC) values of 62.5 µg/mL for the ATCC 90028 strain and 125.0 µg/mL for both the clinical isolate and MTCC 1637 strain. Regarding enzyme inhibition, Terminolic acid inhibits alpha-glucosidase enzymes in Saccharomyces cerevisiae and rat intestines by 21.0% and 10.1%, respectively, and shows a 7.5% inhibition rate against pig pancreas alpha-amylase..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.
Synonyms	2α,6β,23-trihydroxyl oleanolic acid

Chemical Properties

Molecular Weight	504.7
Formula	C₃₀H₄₈O₆
Cas No.	564-13-6
Smiles	[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]3([H])[C@H](O)C[C@@]12C)C(O)=O
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (89.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9814 mL	9.9069 mL	19.8138 mL	99.0688 mL
5 mM	0.3963 mL	1.9814 mL	3.9628 mL	19.8138 mL
10 mM	0.1981 mL	0.9907 mL	1.9814 mL	9.9069 mL
20 mM	0.0991 mL	0.4953 mL	0.9907 mL	4.9534 mL
50 mM	0.0396 mL	0.1981 mL	0.3963 mL	1.9814 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc