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GDF-15 Protein, Human, Recombinant (hFc)
(Synonyms: PTGFB, PLAB, PDF, NAG-1, MIC-1, MIC1, growth differentiation factor 15, GDF-15) Copy Product InfoSynonyms: PTGFB, PLAB, PDF, NAG-1, MIC-1, MIC1, growth differentiation factor 15, GDF-15
Catalog No. TMPY-01073 Copy Product Info
GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $42 | - | In Stock | |
| 10 μg | $65 | - | In Stock | |
| 20 μg | $98 | - | In Stock | |
| 50 μg | $197 | In Stock | In Stock | |
| 100 μg | $335 | 7-10 days | 7-10 days | |
| 200 μg | $573 | 7-10 days | 7-10 days | |
| 500 μg | Preferential | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:92%
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Recombinant Human GFRAL Protein (His Tag) (Mature Form) at 2 μg/mL (100 μL/well) can bind Recombinant Human GDF-15 Protein (Fc Tag), the EC50 is 50-150 ng/mL. |
| Description | GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-hFc |
| Accession Number | Q99988 |
| Construction | A DNA sequence encoding the mature form of human GDF15 (NP_004855.2) (Ala 197-Ile 308) was expressed with the fused Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu 20 |
| Protein Purity | > 90 % as determined by SDS-PAGE  |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | PTGFB, PLAB, PDF, NAG-1, MIC-1, MIC1, growth differentiation factor 15, GDF-15 |
| Research Background | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
| Molecular Weight | 40.6 kDa (predicted); 44 kDa protein (reducing conditions) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: GDF-15 Protein, Human, Recombinant (hFc) chemical structure | GDF-15 Protein, Human, Recombinant (hFc) molecular weight
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