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SHA 68

Name: SHA 68
Brand: TargetMol
SKU: T12895
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12895Cas No. 847553-89-3

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.

SHA 68

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Purity: 99.44%

Catalog No. T12895Cas No. 847553-89-3

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	-	In Stock
5 mg	$83	-	In Stock
10 mg	$135	-	In Stock
25 mg	$272	-	In Stock
50 mg	$436	-	In Stock
100 mg	$698	-	In Stock
1 mL x 10 mM (in DMSO)	$92	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.
Targets&IC50	Ile107:23.8 nM , Asn107:22 nM
In vivo	SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity, vertical rearing, and climbing[1]. SHA 68 (i.v.; 1 mg/kg) exhibits a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg. SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours and a CL of 4.56 mL/min/kg[1].

Chemical Properties

Molecular Weight	445.49
Formula	C₂₆H₂₄FN₃O₃
Cas No.	847553-89-3
Smiles	Fc1ccc(CNC(=O)N2CCN3C(C2)C(OC3=O)(c2ccccc2)c2ccccc2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (561.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2447 mL	11.2236 mL	22.4472 mL	112.2360 mL
5 mM	0.4489 mL	2.2447 mL	4.4894 mL	22.4472 mL
10 mM	0.2245 mL	1.1224 mL	2.2447 mL	11.2236 mL
20 mM	0.1122 mL	0.5612 mL	1.1224 mL	5.6118 mL
50 mM	0.0449 mL	0.2245 mL	0.4489 mL	2.2447 mL
100 mM	0.0224 mL	0.1122 mL	0.2245 mL	1.1224 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc