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SHA 68

Name: SHA 68
Brand: TargetMol
SKU: T12895
Rating: 4.5 (1 reviews)

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Catalog No. T12895Cas No. 847553-89-3

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.

SHA 68

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Catalog No. T12895Cas No. 847553-89-3

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.

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Product Introduction

Bioactivity

Description	SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.
Targets&IC50	Ile107:23.8 nM , Asn107:22 nM
In vivo	SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity, vertical rearing, and climbing[1]. SHA 68 (i.v.; 1 mg/kg) exhibits a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg. SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours and a CL of 4.56 mL/min/kg[1].

Chemical Properties

Molecular Weight	445.49
Formula	C₂₆H₂₄FN₃O₃
Cas No.	847553-89-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (561.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.41 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2447 mL	11.2236 mL	22.4472 mL	112.2360 mL
5 mM	0.4489 mL	2.2447 mL	4.4894 mL	22.4472 mL
10 mM	0.2245 mL	1.1224 mL	2.2447 mL	11.2236 mL
20 mM	0.1122 mL	0.5612 mL	1.1224 mL	5.6118 mL
50 mM	0.0449 mL	0.2245 mL	0.4489 mL	2.2447 mL
100 mM	0.0224 mL	0.1122 mL	0.2245 mL	1.1224 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc