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LyP-1

Catalog No. T40555 CAS 454487-07-1

LyP-1 is a cyclic peptide comprised of 9 amino acids, designed to target and bind selectively to p32 receptors that are overexpressed in a range of tumor-associated cells.

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LyP-1, CAS 454487-07-1

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

LyP-1 is a cyclic peptide comprised of 9 amino acids, designed to target and bind selectively to p32 receptors that are overexpressed in a range of tumor-associated cells.

In vivo

LyP-1 (8 weeks) significantly reduces plaque formation and occupation rates in treated groups, alongside increasing the apoptotic rate of macrophages from hypoxic plaques, compared to a control peptide[1]. Furthermore, for optical imaging purposes, LyP-1 is tagged with a near-infrared fluorophore, Cy5.5. In an experiment involving tumor-bearing BALB/C mice, Cy5.5-LyP-1 (0.8 nmol) was administered via the middle phalanges of the upper extremities at intervals following 4T1 cell inoculation. Recorded fluorescence intensities at days 3, 7, 14, and 21 post-inoculation were progressively higher, evidencing incremental accumulation and demonstrating rates significantly surpassing those in the contralateral lymph nodes (LNs). This co-localization of Cy5.5-LyP-1 with LYVE-1 in LNs indicates a lymphatics-specific binding affinity of the LyP-1 peptide[1].

Molecular Weight	992.14
Formula	C36H65N17O12S2
CAS No.	454487-07-1

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fan Zhang, et al.Imaging tumor-induced sentinel lymph node lymphangiogenesis with LyP-1 peptide. Amino Acids. 2012 Jun;42(6):2343-51. 2. Ningning Song, et al. Recent progress in LyP-1-based strategies for targeted imaging and therapy. Drug Deliv. 2019 Dec;26(1):363-375.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LyP-1 454487-07-1 LyP1 LyP 1 inhibitor inhibit

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