Shopping Cart
Remove All
Your shopping cart is currently empty
Zolunicant
😃Good
Catalog No. T61452Cas No. 188125-42-0
Zolunicant (MM-110) is a potent nicotinic α3β4 receptor inhibitor with an IC50 of 0.90 μM, showing promise in combating addiction. It effectively reduces self-administration of addictive agents such as morphine, cocaine, methamphetamine, nicotine, and ethanol in rat models, indicating its potential as a treatment for various forms of drug abuse [1]. Additionally, Zolunicant exhibits strong leishmanicidal activity against Leishmania amazonensis, expanding its therapeutic prospects [2].
Zolunicant
😃Good
Catalog No. T61452Cas No. 188125-42-0
Zolunicant (MM-110) is a potent nicotinic α3β4 receptor inhibitor with an IC50 of 0.90 μM, showing promise in combating addiction. It effectively reduces self-administration of addictive agents such as morphine, cocaine, methamphetamine, nicotine, and ethanol in rat models, indicating its potential as a treatment for various forms of drug abuse [1]. Additionally, Zolunicant exhibits strong leishmanicidal activity against Leishmania amazonensis, expanding its therapeutic prospects [2].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $970 | 14-16 weeks | 14-16 weeks | |
| 50 mg | $1,980 | 14-16 weeks | 14-16 weeks | |
| 100 mg | $2,500 | 14-16 weeks | 14-16 weeks |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Zolunicant (MM-110) is a potent nicotinic α3β4 receptor inhibitor with an IC50 of 0.90 μM, showing promise in combating addiction. It effectively reduces self-administration of addictive agents such as morphine, cocaine, methamphetamine, nicotine, and ethanol in rat models, indicating its potential as a treatment for various forms of drug abuse [1]. Additionally, Zolunicant exhibits strong leishmanicidal activity against Leishmania amazonensis, expanding its therapeutic prospects [2]. |
| In vitro | Zolunicant (18-MC; 0.01-100 μM) inhibits nicotinic α3β4 receptors, demonstrating an IC50 of 0.90 μM [1]. Additionally, Zolunicant (18-MCOR; 0-20 μg/ml; 24h) exhibits antiamastigote activity against L. amazonensis-infected macrophages, with a Cell Viability Assay revealing a significant reduction in amastigote survival—73%, 84%, and 92% decreases at concentrations of 1, 10, and 20 μg/ml, respectively [2]. |
| In vivo | Zolunicant (18-MC; intravenous administration; 0-20 μg/day for 14 days) effectively reduces morphine self-administration in naïve female Long-Evans derived rats by inhibiting α3β4 nicotinic receptors within the habenulo-interpeduncular pathway. The compound, administered directly into the medial habenula and interpeduncular nucleus, demonstrated significant decreases in morphine intake, evidencing its potential as a therapeutic agent in addiction treatments (Interpeduncular nucleus: F(5,29) = 6.89, P < 0.0001; Medial habenula: F(4,28) = 3.07, P < 0.03) [3]. |
| Molecular Weight | 368.47 |
| Formula | C22H28N2O3 |
| Cas No. | 188125-42-0 |
| Smiles | C(OC)(=O)[C@]12[C@]3([N@](CC(C1)(C[C@@H]3CCOC)[H])CCC4=C2NC=5C4=CC=CC5)[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Zolunicant | purchase Zolunicant | Zolunicant cost | order Zolunicant | Zolunicant chemical structure | Zolunicant in vivo | Zolunicant in vitro | Zolunicant formula | Zolunicant molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.