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TLR7/8-IN-1

Name: TLR7/8-IN-1
Brand: TargetMol
SKU: T38078
Price: 189 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38078Cas No. 2205095-75-4

Alias TLR7/8-IN-1

TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor from patent WO2019220390 (compound 2b), is a valuable compound for autoimmune disease research.

TLR7/8-IN-1

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Purity: 99.99%

Catalog No. T38078Alias TLR7/8-IN-1Cas No. 2205095-75-4

TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor from patent WO2019220390 (compound 2b), is a valuable compound for autoimmune disease research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$189	In Stock	In Stock
5 mg	$479	In Stock	In Stock
10 mg	$718	In Stock	In Stock
25 mg	$1,220	In Stock	In Stock
50 mg	$1,690	In Stock	In Stock
100 mg	$2,270	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor from patent WO2019220390 (compound 2b), is a valuable compound for autoimmune disease research.
In vitro	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor from patent WO2019220390 (compound 2b), is a valuable compound for autoimmune disease research.[1]
Synonyms	TLR7/8-IN-1

Chemical Properties

Molecular Weight	532.68
Formula	C₂₉H₄₀N₈O₂
Cas No.	2205095-75-4
Smiles	Cc1nn(CC23CCC(CC2)(CC3)NC(=O)[C@@H]2COCCN2)c2CCN(Cc12)c1cc(C)nc2n(C)ncc12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (281.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8773 mL	9.3865 mL	18.7730 mL	93.8650 mL
5 mM	0.3755 mL	1.8773 mL	3.7546 mL	18.7730 mL
10 mM	0.1877 mL	0.9386 mL	1.8773 mL	9.3865 mL
20 mM	0.0939 mL	0.4693 mL	0.9386 mL	4.6932 mL
50 mM	0.0375 mL	0.1877 mL	0.3755 mL	1.8773 mL
100 mM	0.0188 mL	0.0939 mL	0.1877 mL	0.9386 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc