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Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody
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Catalog No. TMAB-10606
Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody is a Rabbit antibody targeting Phospho-DOK1 (Tyr362). Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody can be used in WB.
Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody
Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody
😃Good
Catalog No. TMAB-10606
Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody is a Rabbit antibody targeting Phospho-DOK1 (Tyr362). Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody is a Rabbit antibody targeting Phospho-DOK1 (Tyr362). Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region. |
| Tissue Specificity | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human DOK1 around the phosphorylation site of Tyr362 |
| Antigen Species | Human |
| Gene Name | DOK1 |
| Gene ID | |
| Protein Name | Docking protein 1 |
| Uniprot ID | |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
| Molecular Weight | Theoretical: 62 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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