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Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody

Catalog No. TMAB-10606 Copy Product Info
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Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody is a Rabbit antibody targeting Phospho-DOK1 (Tyr362). Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody can be used in WB.

Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-10606

Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody is a Rabbit antibody targeting Phospho-DOK1 (Tyr362). Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody can be used in WB.

Anti-Phospho-DOK1
(Tyr362) Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2237-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody is a Rabbit antibody targeting Phospho-DOK1 (Tyr362). Anti-Phospho-DOK1 (Tyr362) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Dog,Pig,Cow)
Verified Activity
Sample:
JurkaT (Human) Cell Lysate at 30 μg
k562 (human) Cell Lysate at 30 μg
Primary: Anti-phospho-DOK1 (Tyr362) (TMAB-10606) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 62 kD
Observed band size: 62 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationIsoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region.
Tissue SpecificityExpressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundDocking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human DOK1 around the phosphorylation site of Tyr362
Antigen Species
Human
Gene Name
DOK1
Gene ID
1796
Protein Name
Docking protein 1
Uniprot ID
Q99704
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Chemical Properties
Molecular WeightTheoretical: 62 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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