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Anti-PTPH1 Polyclonal Antibody

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Catalog No. TMAB-11916

Anti-PTPH1 Polyclonal Antibody is a Rabbit antibody targeting PTPH1. Anti-PTPH1 Polyclonal Antibody can be used in WB.

Anti-PTPH1 Polyclonal Antibody

Anti-PTPH1 Polyclonal Antibody

😃Good
Catalog No. TMAB-11916
Anti-PTPH1 Polyclonal Antibody is a Rabbit antibody targeting PTPH1. Anti-PTPH1 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PTPH1 Polyclonal Antibody is a Rabbit antibody targeting PTPH1. Anti-PTPH1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Dog,Cow,Horse,Sheep)
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane. Cytoplasm. cytoskeleton.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. PTP-H1 shares homology with the cytoskeletal-associated proteins band 4.1, ezrin, and talin and has been shown to contain a PDZ and band 4.1 domain. These domains are responsible for targeting proteins to the cytoskeleton-membrane interface, as well as mediating protein-protein interactions, recognizing C-terminal valine residues and binding to other PDZ domains. Overexpression of PTP-H1 may reverse transformation induced by oncogenic protein-tyrosine kinases, such as the members of the src family.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human PTPH1/PTPN3
Antigen Species
Human
Gene Name
PTPN3
Gene ID
Protein Name
Tyrosine-protein phosphatase non-receptor type 3
Uniprot ID
Function
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
Chemical Properties
Molecular WeightTheoretical: 104 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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