CASK Protein, Human, Recombinant (GST)

Catalog No. TMPC-00124 Copy Product Info

CASK Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is O14936.

CASK Protein, Human, Recombinant (GST)

Catalog No. TMPC-00124

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CASK Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is O14936.

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10 μg	$1,390	Inquiry	Inquiry

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of CASK was determined to be 3 nmol /min/mg by radioactive kinase assay.
Description	CASK Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is O14936.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	O14936
Synonyms	Protein lin-2 homolog,Peripheral plasma membrane protein CASK,LIN2,hCASK,CASK,Calcium/calmodulin-dependent serine protein kinase
Construction	Recombinant human CASK (1-564) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>90% as determined by SDS-PAGE.
Molecular Weight	~95 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2 contains oneguanylate kinase-like domain, twoL27 domains, onePDZ (DHR) domain, oneprotein kinase domain and oneSH3 domain. CASK / LIN2 is ubiquitously expressed. Expression of CASK / LIN2 is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. CASK / LIN2 is a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. CASK / LIN2 contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. It binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. CASK / LIN2 may mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Defects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Defects in CASK are also the cause of FG syndrome type 4 which is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.