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Imipramine

Name: Imipramine
Brand: TargetMol
SKU: T20025
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T20025Cas No. 50-49-7

Alias Melipramine, HSDB-3100, HSDB3100, HSDB 3100, Dimipressin

Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.

Imipramine

🥰Excellent

Purity: 99.4%

Catalog No. T20025Alias Melipramine, HSDB-3100, HSDB3100, HSDB 3100, DimipressinCas No. 50-49-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$52	In Stock	In Stock
10 mg	$85	In Stock	In Stock
25 mg	$172	In Stock	In Stock
50 mg	$268	-	In Stock
100 mg	$428	-	In Stock
500 mg	$968	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.4%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.
Targets&IC50	placental serotonin transporter (human):32 nM
In vitro	In DLD-1, HCT-116, and SW-480 cell lines, Imipramine (0.5-300 μM; 3 days) inhibited cell viability, with HCT-116 being more sensitive to it compared to DLD-1 and SW-480[1].
In vivo	In male C57BL/6 mice (6-8 weeks old) exposed to repeated social defeat (RSD) and home cage control (HCC), Imipramine (20 mg/kg or 15 mg/kg; administered intraperitoneally or orally, daily for 24 days) reversed RSD-induced social avoidance behavior, significantly increasing interaction time, and significantly decreased stress-induced mRNA levels for IL-6 in brain microglia[4].
Synonyms	Melipramine, HSDB-3100, HSDB3100, HSDB 3100, Dimipressin

Chemical Properties

Molecular Weight	280.41
Formula	C₁₉H₂₄N₂
Cas No.	50-49-7
Smiles	C=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)CCCN(C)C
Relative Density.	1.041g/cm3
Color	Orange
Appearance	Liquid

Storage & Solubility Information

Storage

store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (356.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (17.83 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5662 mL	17.8310 mL	35.6621 mL	178.3103 mL
5 mM	0.7132 mL	3.5662 mL	7.1324 mL	35.6621 mL
10 mM	0.3566 mL	1.7831 mL	3.5662 mL	17.8310 mL
20 mM	0.1783 mL	0.8916 mL	1.7831 mL	8.9155 mL
50 mM	0.0713 mL	0.3566 mL	0.7132 mL	3.5662 mL
100 mM	0.0357 mL	0.1783 mL	0.3566 mL	1.7831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc