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Tilmicosin

Name: Tilmicosin
Brand: TargetMol
SKU: T0777
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0777Cas No. 108050-54-0

Alias LY-177370, EL-870

Tilmicosin (EL-870) is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.

Tilmicosin

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Purity: 99.5%

Catalog No. T0777Alias LY-177370, EL-870Cas No. 108050-54-0

Tilmicosin (EL-870) is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$47	In Stock	In Stock
1 g	$68	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.5%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tilmicosin (EL-870) is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
In vivo	After a subcutaneous injection, tilmicosin is eliminated more slowly from serum and milk, with t1/2 beta S of 29.3 and 41.4 hours, respectively. The apparent volume of distribution of tilmicosin is more than 1 L/kg. The peak serum tilmicosin concentration is 1.56 μg/mL. 6.39 hours after a subcutaneous injection of 10 mg/kg. Tilmicosin is extensively secreted into milk, reaching a maximum concentration of 11.6 μg/mL and having a large AUCmilk/AUCserum ratio of approximately 12:1. Tilmicosin is detectable in milk for 11 days after a single subcutaneous dose.[2]
Synonyms	LY-177370, EL-870

Chemical Properties

Molecular Weight	869.13
Formula	C₄₆H₈₀N₂O₁₃
Cas No.	108050-54-0
Smiles	O([C@H]1[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H]1C)[C@H]4[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H](C)O4
Relative Density.	1.18 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8 mg/mL (9.2 mM), Sonication is recommended.

DMSO: 250 mg/mL (287.64 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1506 mL	5.7529 mL	11.5058 mL	57.5288 mL
5 mM	0.2301 mL	1.1506 mL	2.3012 mL	11.5058 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1151 mL	0.5753 mL	1.1506 mL	5.7529 mL
20 mM	0.0575 mL	0.2876 mL	0.5753 mL	2.8764 mL
50 mM	0.0230 mL	0.1151 mL	0.2301 mL	1.1506 mL
100 mM	0.0115 mL	0.0575 mL	0.1151 mL	0.5753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc