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Anti-CD45 Antibody (6K117)
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Catalog No. TMAY-00449
Alias T200, protein tyrosine phosphatase, receptor type, C, LY5, L-CA, LCA, GP180, CD45R, CD45, B220
Anti-CD45 Antibody (6K117) is a Mouse antibody targeting CD45. Anti-CD45 Antibody (6K117) can be used in WB,IHC-P.
Anti-CD45 Antibody (6K117)
Anti-CD45 Antibody (6K117)
😃Good
Catalog No. TMAY-00449Alias T200, protein tyrosine phosphatase, receptor type, C, LY5, L-CA, LCA, GP180, CD45R, CD45, B220
Anti-CD45 Antibody (6K117) is a Mouse antibody targeting CD45. Anti-CD45 Antibody (6K117) can be used in WB,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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| Description | Anti-CD45 Antibody (6K117) is a Mouse antibody targeting CD45. Anti-CD45 Antibody (6K117) can be used in WB,IHC-P. |
| Alias | T200, protein tyrosine phosphatase, receptor type, C, LY5, L-CA, LCA, GP180, CD45R, CD45, B220 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6K117 |
| Reactivity | Human |
| Verified Activity | 1. Anti-PTPRC mouse monoclonal antibody at 1:500 dilution. -Lane A: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:143 kDa. 2. Immunochemical staining of mouse PTPRC in human spleen with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of mouse PTPRC in human lymphoma with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. |
| Application | WB,IHC-P |
| Recommended Dose | WB: 1:500-1:2000; IHC-P: 1:30-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human CD45/Ptprc. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human CD45/Ptprc |
| Antigen Species | Human |
| Biology Area | Phosphatases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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