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Evodenoson

Name: Evodenoson
Brand: TargetMol
SKU: T31731
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T31731Cas No. 844873-47-8

Alias DE-112, DE112, DE 112, ATL-313, ATL313, ATL 313

Evodenoson (ATL313) is a potent and selective adenosine A2a receptor (A2aR) agonist for the treatment of eye diseases, tumors, and immune system disorders, and may be used in studies of open-angle glaucoma and blood tumors.

Evodenoson

🥰Excellent

Purity: 99.84%

Catalog No. T31731Alias DE-112, DE112, DE 112, ATL-313, ATL313, ATL 313Cas No. 844873-47-8

Pack Size	Price	Availability
1 mg	$250	In Stock
5 mg	$630	In Stock
10 mg	$950	In Stock
25 mg	$1,828	In Stock
50 mg	$2,460	In Stock
100 mg	$3,720	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.84%

ee:100%

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Evodenoson (ATL313) is a potent and selective adenosine A2a receptor (A2aR) agonist for the treatment of eye diseases, tumors, and immune system disorders, and may be used in studies of open-angle glaucoma and blood tumors.
In vivo	The rats were divided into 3 groups: Group 1 received a continuous intravenous infusion of saline given 10 min prior to ischemia and throughout reperfusion (n=8); Group 2 received a continuous intravenous infusion of 10 ng/kg/min of ATL 313 given 10 min prior to ischemia and throughout reperfusion (n=8); and group 3 received an intravenous bolus of ATL 313 (900 ng/Kg body weight) given 10 min prior to ischemia, and continuous intravenous infusion of 10 ng/kg/min of ATL 313 started at 20 min after ischemia and throughout reperfusion (n=8). After the euthanasia of the rats, the hearts were harvested for the assessment of the risk zone and zone of necrosis of the left ventricle. Conclusion: A(2A)AR agonist ATL 313 significantly reduced infarct size and improved LV contractility at the end of reperfusion assessed by LV dp/dt at a dose of 900 ng/Kg. The mechanisms for the observed cardioprotection effect of ATL 313 remain to be determined.[2]
Synonyms	DE-112, DE112, DE 112, ATL-313, ATL313, ATL 313

Chemical Properties

Molecular Weight	499.52
Formula	C₂₃H₂₉N₇O₆
Cas No.	844873-47-8
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(C#CCC4CCN(C(OC)=O)CC4)N3)O[C@H](C(NC5CC5)=O)[C@H]1O
Relative Density.	1.67 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (100.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0019 mL	10.0096 mL	20.0192 mL	100.0961 mL
5 mM	0.4004 mL	2.0019 mL	4.0038 mL	20.0192 mL
10 mM	0.2002 mL	1.0010 mL	2.0019 mL	10.0096 mL
20 mM	0.1001 mL	0.5005 mL	1.0010 mL	5.0048 mL
50 mM	0.0400 mL	0.2002 mL	0.4004 mL	2.0019 mL
100 mM	0.0200 mL	0.1001 mL	0.2002 mL	1.0010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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