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CTP Synthetase-IN-1

Name: CTP Synthetase-IN-1
Brand: TargetMol
SKU: T72505
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72505Cas No. 2338811-71-3

CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.

CTP Synthetase-IN-1

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Purity: 99.18%

Catalog No. T72505Cas No. 2338811-71-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$63	-	In Stock
5 mg	$152	-	In Stock
10 mg	$255	-	In Stock
25 mg	$529	-	In Stock
50 mg	$893	-	In Stock
100 mg	$1,530	-	In Stock
1 mL x 10 mM (in DMSO)	$169	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.
Targets&IC50	CTPS2 (human):18 nM, CTPS1(human):32 nM
In vivo	In the Mouse collagen-induced arthritis (CIA) model, CTP Synthetase-IN-1 (10 mg/kg, p.o; twice daily; for 18 days) exhibited significant pharmacological responses[1].

Chemical Properties

Molecular Weight	512.53
Formula	C₂₀H₁₉F₃N₆O₃S₂
Cas No.	2338811-71-3
Smiles	O=C(NC1=NC=C(C=C1)C2=NC(=CN=C2)C(F)(F)F)C(C=3N=C(SC3)NS(=O)(=O)C4CC4)(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (156.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9511 mL	9.7555 mL	19.5111 mL	97.5553 mL
5 mM	0.3902 mL	1.9511 mL	3.9022 mL	19.5111 mL
10 mM	0.1951 mL	0.9756 mL	1.9511 mL	9.7555 mL
20 mM	0.0976 mL	0.4878 mL	0.9756 mL	4.8778 mL
50 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9511 mL
100 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.9756 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc