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Anti-MBD2 Antibody (6R377)
😃Good
Catalog No. TMAB-08641
Anti-MBD2 Antibody (6R377) is a Rabbit antibody targeting MBD2. Anti-MBD2 Antibody (6R377) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM.
Anti-MBD2 Antibody (6R377)
Anti-MBD2 Antibody (6R377)
😃Good
Catalog No. TMAB-08641
Anti-MBD2 Antibody (6R377) is a Rabbit antibody targeting MBD2. Anti-MBD2 Antibody (6R377) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-MBD2 Antibody (6R377) is a Rabbit antibody targeting MBD2. Anti-MBD2 Antibody (6R377) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM. |
| Ig Type | IgG |
| Clone | 6R377 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:1000-5000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:50-200; IP: 1:20-50; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Nuclear, in discrete foci. Detected at replication foci in late S phase. |
| Tissue Specificity | Highly expressed in brain, heart, kidney, stomach, testis and placenta. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain. |
| Immunogen | A synthesized peptide: human MBD2 |
| Antigen Species | Human |
| Gene Name | MBD2 |
| Gene ID | |
| Protein Name | Methyl-CpG-binding domain protein 2 |
| Uniprot ID | |
| Function | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
| Molecular Weight | Theoretical: 43 kDa. Actual: 29, 43 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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