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Tau Protein Phosphorylation-IN-1
Catalog No. T213552 Copy Product Info
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Tau ProteinPhosphorylation-IN-1 is a tau protein phosphorylation inhibitor that effectively protects PC12 cells from Aβ25-35-induced cytotoxicity (EC50 = 1.93 μM) and is capable of crossing the blood-brain barrier. It reverses tau protein hyperphosphorylation both in vitro and in vivo, significantly suppresses the expression of immune-related cytotoxic factors, blocks the MAPK and NF-κB signaling pathways, and reduces the levels of RAGE and apoptosis factor Bax/Bcl-2. In Alzheimer's disease mouse models, Tau ProteinPhosphorylation-IN-1 alleviates neuronal damage and improves learning and memory capabilities. It is applicable for Alzheimer's disease research.
Tau Protein Phosphorylation-IN-1
Copy Product Info🥰Excellent
Catalog No. T213552
Tau ProteinPhosphorylation-IN-1 is a tau protein phosphorylation inhibitor that effectively protects PC12 cells from Aβ25-35-induced cytotoxicity (EC50 = 1.93 μM) and is capable of crossing the blood-brain barrier. It reverses tau protein hyperphosphorylation both in vitro and in vivo, significantly suppresses the expression of immune-related cytotoxic factors, blocks the MAPK and NF-κB signaling pathways, and reduces the levels of RAGE and apoptosis factor Bax/Bcl-2. In Alzheimer's disease mouse models, Tau ProteinPhosphorylation-IN-1 alleviates neuronal damage and improves learning and memory capabilities. It is applicable for Alzheimer's disease research.
Tau Protein Phosphorylation-IN-1
Cas No. 3075165-36-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Storage & Solubility Information
| Description | Tau ProteinPhosphorylation-IN-1 is a tau protein phosphorylation inhibitor that effectively protects PC12 cells from Aβ25-35-induced cytotoxicity (EC50 = 1.93 μM) and is capable of crossing the blood-brain barrier. It reverses tau protein hyperphosphorylation both in vitro and in vivo, significantly suppresses the expression of immune-related cytotoxic factors, blocks the MAPK and NF-κB signaling pathways, and reduces the levels of RAGE and apoptosis factor Bax/Bcl-2. In Alzheimer's disease mouse models, Tau ProteinPhosphorylation-IN-1 alleviates neuronal damage and improves learning and memory capabilities. It is applicable for Alzheimer's disease research. |
| In vitro | Tau Protein Phosphorylation-IN-1 (compound B1) shows no toxicity to PC12 cells at a concentration of 30 μM for 24 hours and effectively counters Aβ 25-35-induced cytotoxicity at 10 μM. In PC12 cells exposed to Aβ 25-35, Tau Protein Phosphorylation-IN-1 (2.5-10 μM, 24 hours) exhibits neuroprotective effects through various mechanisms. It significantly reduces tau phosphorylation at Thr181, Thr205, and Ser396 sites, inhibits the phosphorylation of MAPKs (p38, ERK, JNK) and NF-κB, reverses Aβ-induced upregulation of iNOS and COX-2 expression, regulates apoptosis-related proteins Bax/Bcl-2 expression, and suppresses RAGE. |
| In vivo | Tau Protein Phosphorylation-IN-1, administered intraperitoneally at doses of 2.5, 5, and 10 mg/kg once daily for 28 days, effectively enhances cognitive function, reduces excessive tau protein phosphorylation, and suppresses neuroinflammation in a mouse model of Alzheimer's disease. |
| Molecular Weight | 628.9 |
| Formula | C39H56N4O3 |
| Cas No. | 3075165-36-2 |
| Smiles | C(OCCN1C(=NN=N1)C2=CC=CC=C2)(=O)[C@]34[C@](C=5[C@@](C)(CC3)[C@@]6(C)[C@](CC5)([C@]7(C)[C@@](CC6)(C(C)(C)[C@@H](O)CC7)[H])[H])(CC(C)(C)CC4)[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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