NKp30/NCR3 Protein, Human, Recombinant (His)

Name: NKp30/NCR3 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01145
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: NKp30, NCR3, natural cytotoxicity triggering receptor 3, MALS, LY117, DAAP-90L16.3, CD337, 1C7) Copy Product Info

Synonyms: NKp30, NCR3, natural cytotoxicity triggering receptor 3, MALS, LY117, DAAP-90L16.3, CD337, 1C7

Catalog No. TMPY-01145 Copy Product Info

NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$52	-	In Stock
10 µg	$81	-	In Stock
20 µg	$129	-	In Stock
50 µg	$255	-	In Stock
100 µg	$437	7-10 days	7-10 days
200 µg	$747	7-10 days	7-10 days
500 µg	$1,520	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:SDS-PAGE: 98.3%; SEC-HPLC: 96.0%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1.Measured by its binding ability in a functional ELISA. 2. Immobilized human NCR3 at 10μg/mL (100μL/well) can bind human B7-H6, the EC50 of human B7-H6 is 20-100ng/mL.
Description	NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	O14931-1
Construction	A DNA sequence encoding the extracellular domain (Met 1-Gly 135) of human NCR3 (NP_667341.1) precursor was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Leu 19
Protein Purity	≥ 97 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ,
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	NKp30, NCR3, natural cytotoxicity triggering receptor 3, MALS, LY117, DAAP-90L16.3, CD337, 1C7
Research Background	Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.

Chemical Properties

Molecular Weight

14.4 kDa (predicted); 22-28 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.