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Methyl alpha-eleostearate

Name: Methyl alpha-eleostearate
Brand: TargetMol
SKU: T36889
Rating: 4.5 (1 reviews)

(Synonyms: Methyl α-eleostearate) Copy Product Info

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Synonyms: Methyl α-eleostearate

Catalog No. T36889 Copy Product Info

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Methyl alpha-eleostearate is a conjugated polyunsaturated fatty acid commonly found in plant seed oils that exhibits antitumor activity.

Cas No. 4175-47-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$168	35 days	35 days
5 mg	$659	35 days	35 days
10 mg	$986	35 days	35 days
25 mg	$1,430	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	Methyl alpha-eleostearate is a conjugated polyunsaturated fatty acid commonly found in plant seed oils that exhibits antitumor activity.
In vitro	Methods: Human colorectal cancer Caco-2 cells were seeded at 2 × 10³ cells per well and cultured for 24 hours. Purified Methyl alpha-eleostearate was added and the cells were treated for 24 hours; cell viability was then assessed using the WST-1 assay. Results: Methyl alpha-eleostearate inhibited Caco-2 cell proliferation in a dose-dependent manner; at 12.5 μM, cell survival was only 19%. [1] Methods: Following treatment with Methyl alpha-eleostearate, the levels of DNA fragmentation—a hallmark of apoptosis—were detected in Caco-2 cells using an ELISA assay. Results: Methyl alpha-eleostearate significantly induced apoptosis in Caco-2 cells, resulting in characteristic DNA fragmentation. [1] Methods: DLD-1 cells were treated with 0–20 μM Methyl alpha-eleostearate or 20 μM linoleic acid/CLA for 12 hours. Phospholipid hydroperoxides (PCOOH, PEOOH) were measured by CL-HPLC, and lipid peroxidation products were determined using the TBARS method. Results: Methyl alpha-eleostearate caused a dose-dependent increase in PCOOH, PEOOH, and TBARS levels.[2]
In vivo	Methods: Nude mice were subcutaneously inoculated with DLD-1 cells and randomly divided into a control group and a tung oil fatty acid group (rich in Methyl alpha-eleostearate). The experimental oil (50 mg) was administered orally every 2 days for 32 days, and tumor weight, body weight, and liver weight were recorded. Results: Tumor weight in the tung oil (Methyl alpha-eleostearate) group decreased by approximately 70%; there were no significant differences in body weight or liver weight among the mice, indicating good in vivo safety. [2]
Synonyms	Methyl α-eleostearate

Chemical Properties

Molecular Weight	292.46
Formula	C₁₉H₃₂O₂
Cas No.	4175-47-7
Smiles	C(CC/C=C\C=C\C=C\CCCC)CCCCC(OC)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (82.06 mM), Sonication is recommended.

Ethanol: 100 mg/mL (341.93 mM), Sonication is recommended.

DMF: 24 mg/mL (82.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.4193 mL	17.0964 mL	34.1927 mL	170.9636 mL
5 mM	0.6839 mL	3.4193 mL	6.8385 mL	34.1927 mL
10 mM	0.3419 mL	1.7096 mL	3.4193 mL	17.0964 mL
20 mM	0.1710 mL	0.8548 mL	1.7096 mL	8.5482 mL
50 mM	0.0684 mL	0.3419 mL	0.6839 mL	3.4193 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Methyl alpha-eleostearateMethyl a-eleostearate9(Z),11(E),13(E)Octadecatrienoic Acid methyl ester9(Z),11(E),13(E) Octadecatrienoic Acid methyl ester

Related Tags: Methyl alpha-eleostearate chemical structure | Methyl alpha-eleostearate in vivo | Methyl alpha-eleostearate in vitro | Methyl alpha-eleostearate formula | Methyl alpha-eleostearate molecular weight