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Anti-Prostatic Acid Phosphatase Antibody (4E793)
😃Good
Catalog No. TMAY-01380
Alias Ppal, PAP, Lap, FRAP, acid phosphatase, prostate, A030005E02Rik, 9.104100899-104272570.1, 5'-NT
Anti-Prostatic Acid Phosphatase Antibody (4E793) is a Rabbit antibody targeting Prostatic Acid Phosphatase. Anti-Prostatic Acid Phosphatase Antibody (4E793) can be used in ELISA.
Anti-Prostatic Acid Phosphatase Antibody (4E793)
Anti-Prostatic Acid Phosphatase Antibody (4E793)
😃Good
Catalog No. TMAY-01380Alias Ppal, PAP, Lap, FRAP, acid phosphatase, prostate, A030005E02Rik, 9.104100899-104272570.1, 5'-NT
Anti-Prostatic Acid Phosphatase Antibody (4E793) is a Rabbit antibody targeting Prostatic Acid Phosphatase. Anti-Prostatic Acid Phosphatase Antibody (4E793) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | Ppal, PAP, Lap, FRAP, acid phosphatase, prostate, A030005E02Rik, 9.104100899-104272570.1, 5'-NT |
| Ig Type | Rabbit IgG |
| Clone | 4E793 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Prostatic Acid Phosphatase / ACPP (rh Prostatic Acid Phosphatase / ACPP; TMPY-02155; NP_001127666.1; Met1-Lys382). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Prostatic Acid Phosphatase / ACPP protein (TMPY-02155) |
| Antigen Species | Human |
| Biology Area | Phosphatases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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