Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 663.00 | |
25 mg | In stock | $ 1,280.00 | |
50 mg | In stock | $ 1,750.00 | |
100 mg | In stock | $ 2,370.00 |
Description | Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS). |
Targets&IC50 | 5-HT4 receptor:115 nM (Ki) |
In vitro | Renzapride was selective for serotonergic receptors and, in particular, had high affinity for human 5-HT(3) and guinea-pig 5-HT(4) receptors (K(i) 17 and 477 nm, respectively)[1]. |
In vivo | Renzapride(BRL 24924)(0.5-1 mg/kg) and another 5-HT1P antagonist, N-acetyl-5-hydroxytryptamine-5-hydroxytryptamine amide (5 mg/kg), significantly increased the rate of emptying of 51Cr-labeled liquid meals from the mouse stomach[2]. |
Synonyms | BRL 24924 |
Molecular Weight | 323.82 |
Formula | C16H22ClN3O2 |
CAS No. | 112727-80-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (30.88 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Renzapride 112727-80-7 GPCR/G Protein Neuroscience 5-HT Receptor BRL-24924 BRL24924 BRL 24924 inhibitor inhibit