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Renzapride

Name: Renzapride
Brand: TargetMol
SKU: T38507
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38507Cas No. 112727-80-7

Alias BRL 24924

Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS).

Renzapride

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Purity: 99.09%

Catalog No. T38507Alias BRL 24924Cas No. 112727-80-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
2 mg	$133	In Stock	In Stock
5 mg	$223	In Stock	In Stock
10 mg	$398	In Stock	In Stock
25 mg	$768	In Stock	In Stock
50 mg	$1,050	In Stock	In Stock
100 mg	$1,420	-	In Stock
200 mg	$1,890	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.09%

ee:100%

Appearance:Solid

Color:White to Yellow

Resource Download

COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS).
Targets&IC50	5-HT4 receptor:115 nM (Ki)
In vitro	Renzapride was selective for serotonergic receptors and, in particular, had high affinity for human 5-HT(3) and guinea-pig 5-HT(4) receptors (K(i) 17 and 477 nm, respectively)[1].
In vivo	Renzapride(BRL 24924)(0.5-1 mg/kg) and another 5-HT1P antagonist, N-acetyl-5-hydroxytryptamine-5-hydroxytryptamine amide (5 mg/kg), significantly increased the rate of emptying of 51Cr-labeled liquid meals from the mouse stomach[2].
Synonyms	BRL 24924

Chemical Properties

Molecular Weight	323.82
Formula	C₁₆H₂₂ClN₃O₂
Cas No.	112727-80-7
Smiles	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN2CCC[C@@H]1C2
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (30.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0881 mL	15.4407 mL	30.8814 mL	154.4068 mL
5 mM	0.6176 mL	3.0881 mL	6.1763 mL	30.8814 mL
10 mM	0.3088 mL	1.5441 mL	3.0881 mL	15.4407 mL
20 mM	0.1544 mL	0.7720 mL	1.5441 mL	7.7203 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc