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2OH-BNPP1

Name: 2OH-BNPP1
Brand: TargetMol
SKU: T14022
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14022Cas No. 833481-73-5

2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.

2OH-BNPP1

🥰Excellent

Purity: 98.45%

Catalog No. T14022Cas No. 833481-73-5

2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$63	In Stock	In Stock
2 mg	$90	In Stock	In Stock
5 mg	$161	In Stock	In Stock
10 mg	$283	In Stock	In Stock
25 mg	$583	In Stock	In Stock
50 mg	$833	In Stock	In Stock
100 mg	$1,150	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$171	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.45%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
In vitro	2OH-BNPP1 disrupts TGFβ signaling by hindering the phosphorylation of key proteins involved in both the canonical and non-canonical TGFβ pathways across a variety of cancerous and normal cell lines in a dose-dependent manner[1]. At concentrations ranging from 0.1 to 50 μM, it effectively suppresses TGFβ signaling in a dose-dependent fashion.
In vivo	2OH-BNPP1 (50 mg/kg) inhibits TGFβ signaling in vivo and significantly reduces phosphorylated SMAD2 levels in tumor-bearing mice[1].

Chemical Properties

Molecular Weight	297.36
Formula	C₁₆H₁₉N₅O
Cas No.	833481-73-5
Smiles	CC(C)(C)n1nc(Cc2ccccc2O)c2c(N)ncnc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: ≥ 100 mg/mL (336.30 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (11.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3629 mL	16.8146 mL	33.6293 mL	168.1464 mL
5 mM	0.6726 mL	3.3629 mL	6.7259 mL	33.6293 mL
10 mM	0.3363 mL	1.6815 mL	3.3629 mL	16.8146 mL
20 mM	0.1681 mL	0.8407 mL	1.6815 mL	8.4073 mL
50 mM	0.0673 mL	0.3363 mL	0.6726 mL	3.3629 mL
100 mM	0.0336 mL	0.1681 mL	0.3363 mL	1.6815 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc