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12R-LOX-IN-2

Name: 12R-LOX-IN-2
Brand: TargetMol
SKU: T77677
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77677Cas No. 3026677-37-9

12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 may be useful in the study of psoriasis and other skin-associated inflammatory diseases.

12R-LOX-IN-2

🥰Excellent

Purity: 99.84%

Catalog No. T77677Cas No. 3026677-37-9

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$45	In Stock
25 mg	$90	In Stock
50 mg	$139	In Stock
100 mg	$230	In Stock
200 mg	$339	In Stock

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Batch Information

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Purity:99.84%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	271.31
Formula	C₁₉H₁₃NO
Cas No.	3026677-37-9
Smiles	OC=1C=CC(C2=NC=3C=CC=CC3C=C2)=C4C=CC=CC14

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (184.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6858 mL	18.4291 mL	36.8582 mL	184.2910 mL
5 mM	0.7372 mL	3.6858 mL	7.3716 mL	36.8582 mL
10 mM	0.3686 mL	1.8429 mL	3.6858 mL	18.4291 mL
20 mM	0.1843 mL	0.9215 mL	1.8429 mL	9.2146 mL
50 mM	0.0737 mL	0.3686 mL	0.7372 mL	3.6858 mL
100 mM	0.0369 mL	0.1843 mL	0.3686 mL	1.8429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc