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(R)-Equol

Name: (R)-Equol
Brand: TargetMol
SKU: T13443
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13443Cas No. 221054-79-1

Alias (+)-Equol

(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.

(R)-Equol

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Purity: 99.59%

Catalog No. T13443Alias (+)-EquolCas No. 221054-79-1

(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$86	In Stock	In Stock
100 mg	$129	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
Targets&IC50	ERα:27.4 nM (Ki), ERβ:15.4 nM (Ki)
In vitro	(R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) [2].
In vivo	In animals, (R)-Equol significantly reduces the number of palpable tumors over time compared to controls (P=0.002). The number of palpable tumors per rat in the (R)-Equol-fed group is significantly lower than in rats treated with S-(-)equol (P=0.008). (R)-Equol-fed animals exhibit 43% fewer tumors than the control group, with this difference being highly statistically significant (P=0.004). The number of tumors per tumor-bearing animal is significantly lower in (R)-Equol-fed animals compared to controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol-fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) compared to controls (9.9±1.4 mg). Feeding the (R)-Equol diet also results in significantly increased tumor latency (P=0.003) [3].
Synonyms	(+)-Equol

Chemical Properties

Molecular Weight	242.27
Formula	C₁₅H₁₄O₃
Cas No.	221054-79-1
Smiles	OC1=CC=C(C=C1)[C@@H]1COC2=C(C1)C=CC(O)=C2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (412.76 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1276 mL	20.6381 mL	41.2763 mL	206.3813 mL
5 mM	0.8255 mL	4.1276 mL	8.2553 mL	41.2763 mL
10 mM	0.4128 mL	2.0638 mL	4.1276 mL	20.6381 mL
20 mM	0.2064 mL	1.0319 mL	2.0638 mL	10.3191 mL
50 mM	0.0826 mL	0.4128 mL	0.8255 mL	4.1276 mL
100 mM	0.0413 mL	0.2064 mL	0.4128 mL	2.0638 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc