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MAK683-CH2CH2COOH
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Catalog No. T13765Cas No. 2639882-68-9
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) and, together with a VHL ligand for the E3 ubiquitin ligase, has been used to design EED-Targeted PROTACs, specifically EED degrader-1 and PROTAC EED degrader-2 [1].
MAK683-CH2CH2COOH
😃Good
Catalog No. T13765Cas No. 2639882-68-9
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) and, together with a VHL ligand for the E3 ubiquitin ligase, has been used to design EED-Targeted PROTACs, specifically EED degrader-1 and PROTAC EED degrader-2 [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $3,680 | 8-10 weeks | |
| 50 mg | $5,520 | 8-10 weeks | |
| 100 mg | $8,280 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) and, together with a VHL ligand for the E3 ubiquitin ligase, has been used to design EED-Targeted PROTACs, specifically EED degrader-1 and PROTAC EED degrader-2 [1]. |
| In vitro | With 14 days treatment, MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI 50 of 14 nM [1]. |
| Molecular Weight | 448.45 |
| Formula | C23H21FN6O3 |
| Cas No. | 2639882-68-9 |
| Relative Density. | 1.50 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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