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PolQi1
🥰Excellent
Catalog No. T89335Cas No. 2607139-80-8
PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.
PolQi1
🥰Excellent
Purity: 98.97%
Catalog No. T89335Cas No. 2607139-80-8
PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,970 | In Stock | |
| 200 mg | $2,690 | In Stock |
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Purity:98.97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy. |
| In vitro | Methods: SpCas9-inducible HEK293T cells and hiPSCs were treated with 0.3–10 μM PolQi1 in combination with AZD7648 (1 μM) for 3 hours to evaluate HDR knock-in efficiency and InDel levels. Results: In HEK293T cells, 3 μM PolQi1 increased HDR efficiency by 3.9-fold and reduced InDels by 17.4-fold, with no additional benefit observed at 10 μM. In hiPSCs, HDR efficiency was enhanced by 6.6-fold and InDels were reduced by 2.3-fold.[1] |
| Molecular Weight | 448.77 |
| Formula | C18H14ClF5N4O2 |
| Cas No. | 2607139-80-8 |
| Smiles | C(N(C)C1=C(F)C(Cl)=C(F)C=C1)(=O)[C@H]2N(C(=O)NC2)C3=CC(C(F)(F)F)=CC(C)=N3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 3 mg/mL (6.68 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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