Shopping Cart

Remove All
Your shopping cart is currently empty

Tolazoline hydrochloride

Name: Tolazoline hydrochloride
Brand: TargetMol
SKU: T1680
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1680Cas No. 59-97-2

Alias Tolazoline HCl, NSC35110 (hydrochloride), Imidaline hydrochloride, Imidaline (hydrochloride), Benzidazol hydrochloride

Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn.

Tolazoline hydrochloride

🥰Excellent

Purity: 99.67%

Catalog No. T1680Alias Tolazoline HCl, NSC35110 (hydrochloride), Imidaline hydrochloride, Imidaline (hydrochloride), Benzidazol hydrochlorideCas No. 59-97-2

Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn.

Pack Size	Price	Availability
1 g	$30	In Stock
5 g	$55	In Stock
10 g	$77	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.67%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn.
In vivo	In cases of persistent pulmonary hypertension of the newborn (PPHN), Tolazoline acts as a pulmonary vasodilator, effectively reducing pulmonary vascular resistance (PVR) and pulmonary arterial pressure. Additionally, within the human radial artery, Tolazoline blocks α-adrenergic activity, significantly counteracting vascular spasms.
Synonyms	Tolazoline HCl, NSC35110 (hydrochloride), Imidaline hydrochloride, Imidaline (hydrochloride), Benzidazol hydrochloride

Chemical Properties

Molecular Weight	196.68
Formula	C₁₀H₁₃ClN₂
Cas No.	59-97-2
Smiles	Cl.C(C1=NCCN1)c1ccccc1
Relative Density.	1.09g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 36 mg/mL (183.04 mM), Sonication is recommended.

DMSO: 55 mg/mL (279.64 mM), Sonication is recommended.

Ethanol: 37 mg/mL (188.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0844 mL	25.4220 mL	50.8440 mL	254.2201 mL
5 mM	1.0169 mL	5.0844 mL	10.1688 mL	50.8440 mL
10 mM	0.5084 mL	2.5422 mL	5.0844 mL	25.4220 mL
20 mM	0.2542 mL	1.2711 mL	2.5422 mL	12.7110 mL
50 mM	0.1017 mL	0.5084 mL	1.0169 mL	5.0844 mL
100 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5422 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc