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ROS-generating agent 1

Name: ROS-generating agent 1
Brand: TargetMol
SKU: T77762
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77762Cas No. 2369030-41-9

Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular TrxR protein levels and promotes ROs-dependent apoptosis and ferroptosis in NCI-H460 cells.

ROS-generating agent 1

🥰Excellent

Purity: 99.67%

Catalog No. T77762Cas No. 2369030-41-9

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$198	In Stock
50 mg	$372	In Stock
100 mg	$622	In Stock
500 mg	$1,280	In Stock

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Batch Information

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Purity:99.67%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	411.34
Formula	C₂₁H₁₅F₆NO
Cas No.	2369030-41-9
Smiles	C(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3
Relative Density.	1.363 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (109.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4311 mL	12.1554 mL	24.3108 mL	121.5539 mL
5 mM	0.4862 mL	2.4311 mL	4.8622 mL	24.3108 mL
10 mM	0.2431 mL	1.2155 mL	2.4311 mL	12.1554 mL
20 mM	0.1216 mL	0.6078 mL	1.2155 mL	6.0777 mL
50 mM	0.0486 mL	0.2431 mL	0.4862 mL	2.4311 mL
100 mM	0.0243 mL	0.1216 mL	0.2431 mL	1.2155 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc