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SB-366791

Name: SB-366791
Brand: TargetMol
SKU: T6977
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6977Cas No. 472981-92-3

Alias SB366791

SB-366791 is a new and selective cinnamide TRPV1 antagonist.

SB-366791

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Purity: 99.51%

Catalog No. T6977Alias SB366791Cas No. 472981-92-3

SB-366791 is a new and selective cinnamide TRPV1 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$38	In Stock	In Stock
25 mg	$81	In Stock	In Stock
50 mg	$128	In Stock	In Stock
100 mg	$212	In Stock	In Stock
200 mg	$315	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.51%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

SB-366791 AI Summary

SB-366791 exhibits a range of biological activities across various assays and systems. It shows potent antagonistic activity against the human transient receptor potential vanilloid type 1 (TRPV1) channel, with pKb and IC50 values of 7.7, 270.0 nM in CHO cells, and 190.0 nM in HEK293 cells, respectively. It also acts as an agonist at this receptor, albeit with low efficacy. Moreover, it demonstrates moderate to high antiplasmodial activity against Plasmodium falciparum strains, with IC50 values ranging from 10,000.0 nM to 12,589.25 nM. In the antiviral context, SB-366791 shows inhibitory bioactivity against SARS-CoV-2, reducing cytotoxicity in Caco-2 and VERO-6 cells, with variable inhibition percentages. Additionally, it exhibits potent inhibition of human HDAC6 enzyme with an IC50 of 285.7 nM and blockade of the human TRPM8 and mouse TRPM1 channels. The compound does not significantly inhibit rat brain FAAH, with an IC50 greater than 10,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SB-366791 is a new and selective cinnamide TRPV1 antagonist.
Targets&IC50	TRPV1:5.7 nM
Synonyms	SB366791

Chemical Properties

Molecular Weight	287.74
Formula	C₁₆H₁₄ClNO₂
Cas No.	472981-92-3
Smiles	COC1=CC=CC(NC(=O)\C=C\C2=CC=C(Cl)C=C2)=C1
Relative Density.	1.265g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (868.84 mM), Sonication is recommended.

Ethanol: 2.9 mg/mL (10.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4754 mL	17.3768 mL	34.7536 mL	173.7680 mL
5 mM	0.6951 mL	3.4754 mL	6.9507 mL	34.7536 mL
10 mM	0.3475 mL	1.7377 mL	3.4754 mL	17.3768 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1738 mL	0.8688 mL	1.7377 mL	8.6884 mL
50 mM	0.0695 mL	0.3475 mL	0.6951 mL	3.4754 mL
100 mM	0.0348 mL	0.1738 mL	0.3475 mL	1.7377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc